PMID: 9186570May 23, 1997Paper

In vivo studies on genotoxicity of pure and commercial linuron

Mutation Research
G Scassellati-SforzoliniB L Pool-Zobel

Abstract

The ureic herbicide linuron [3-(3, 4-dichlorophenyl)-1-methoxy-1-methylurea] (CAS 330-55-2) was investigated for genotoxicity in a series of in vivo experiments. Since human exposure to herbicides is not only to the active principles, but also to all the chemicals present in the commercial formulation, we tested both pure and commercial linuron. Groups of rats were treated with gavage containing different doses of the herbicide (pure compound or commercial formulation) for 14 days. The doses were 150, 300 and 450 mg/kg b.wt. for the pure compound and 315.8, 631.6 and 947.4 mg/kg b.wt. for the commercial formulation (47.5% of linuron). Faeces and urine were collected at regular intervals. Urine specimens were analysed for their mutagenic metabolites, thioethers and D-glucaric acid content. Faeces extracts were tested for mutagenicity. Linuron's ability to cause DNA damage and cytogenetic effects was also investigated after treating groups of rats once with different doses of pure or commercial linuron. DNA single-strand breaks were assessed in rat liver using the alkaline elution technique and the single-cell microgel electrophoresis assay (SCGE: 'comet' assay), and in rat testes cells with the SCGE assay. Micronuclei induction ...Continue Reading

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Citations

Mar 16, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S W ChiuD Moore
Mar 6, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·E RojasM Valverde
Jan 29, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M MorettiR Pasquini
Nov 23, 2006·Mutation Research·Brian BurlinsonUNKNOWN In Vivo Comet Assay Workgroup, part of the Fourth International Workgroup on Genotoxicity Testing
May 2, 2006·Acta Biologica Hungarica·F Kaymak, F D Gökalp Muranli
Oct 26, 2014·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Kunio WadaKyomu Matsumoto
Feb 23, 2011·PloS One·Imran ShahDavid J Dix
Jan 14, 2012·Mutation Research·Tomoyasu ToyoizumiKohji Yamakage
Jun 7, 2014·Ecotoxicology and Environmental Safety·Rayenne SariaLaury Gauthier
Feb 27, 2007·Neurotoxicology and Teratology·M J WolanskyK M Crofton
May 19, 2005·Mutagenesis·Susanne Brendler-SchwaabGünter Speit

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