In vivo studies on hepato-renal impairments in freshwater fish Cyprinus carpio following exposure to sublethal concentrations of sodium cyanide

Environmental Science and Pollution Research International
M David, R M Kartheek

Abstract

Reactive oxygen species is an inevitable composite of aerobic systems that could channelize their lethality by imparting oxidative stress under a stressful environment. Cyanide is an important environmental toxicant that could be responsible in the resulting detrimental health issues of aquatic fauna. The present effort investigates the possibilities of hepato-renal damage in freshwater fish Cyprinus carpio following exposure to sublethal concentrations of sodium cyanide (NaCN). Fish were exposed to 0.1 mg/L of NaCN for 10 days (E1) and 20 days (E2) and were further subjected to recovery for 14 days (R) in NaCN-free medium. Liver tissue exhibited a significant decline in activity of catalase, superoxide dismutase, glutathione peroxidase, and glutathione S-transferase enzymes in exposed fish, unlike in control (C). Subsequent levels of lipid peroxidation elevation at 'E1' and 'E2' suggested oxidative damage to hepatocytes. This was further confirmed through a histopathological evaluation which indicated important findings like lymphocytic infiltration and necrosis in liver and tubular and glomerular degeneration in renal organ. The investigation suggests biochemical and histopathological alterations in fish following exposure to...Continue Reading

References

Jan 1, 1978·Methods in Enzymology·J A Buege, S D Aust
Apr 15, 1975·Biochemical Pharmacology·G E IsomJ L Way
Mar 1, 1966·American Journal of Public Health and the Nation's Health·F W Gilcreas
Feb 1, 1994·Free Radical Biology & Medicine·D K St ClairW H St Clair
Sep 1, 1995·The American Journal of Emergency Medicine·D YenJ F Deng
Jan 1, 1994·American Journal of Respiratory Cell and Molecular Biology·B Meyrick, M A Magnuson
Aug 26, 1998·Biochemical Pharmacology·J HuangP J O'Brien
Feb 25, 2000·The International Journal of Biochemistry & Cell Biology·J M Matés, F M Sánchez-Jiménez
Dec 18, 2002·Ecotoxicology and Environmental Safety·Mário Pacheco, Maria Ana Santos
Jan 29, 2003·Ecotoxicology and Environmental Safety·Edith FantaSandra Freiberger
Feb 28, 2003·Biology of Reproduction·Matilde MaiorinoLeopold Flohe
Aug 21, 2003·Ecotoxicology and Environmental Safety·Iqbal SayeedSheikh Raisuddin
Oct 25, 2003·Journal of Fish Diseases·C Agius, R J Roberts
Feb 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Olivier BaudPaul A Rosenberg
Sep 6, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Stamatis VarsamosGuy Charmantier
Mar 21, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Diana Amaral MonteiroAna Lúcia Kalinin
Mar 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Li YuMichael Lenardo
Aug 19, 2007·Nature·Toren FinkelMaria A Blasco
Sep 8, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Volodymyr I Lushchak, Tetyana V Bagnyukova
Feb 26, 2008·Cell·Derrick J RossiIrving L Weissman
Mar 1, 2008·Ecotoxicology and Environmental Safety·M L BallesterosM A Bistoni
Apr 19, 2008·Nature Chemical Biology·Christine C Winterbourn
May 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jose C JuarezFernando Doñate
May 5, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·J Renugadevi, S Milton Prabu
Jun 13, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Mark A Perazella
Jun 19, 2009·Fish Physiology and Biochemistry·Omolara Titilayo AkinsikuAdeyinka Afolayan
Dec 17, 2009·Journal of Hazardous Materials·Neha GuptaV K Agarwal
Feb 26, 2010·International Journal of Cell Biology·Simone FuldaAfshin Samali
Aug 4, 2010·Archives of Environmental Contamination and Toxicology·Charlene Cavalheiro de MenezesVera Maria Morsch
Aug 18, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·John BostockRichard Corner
Nov 16, 2010·Aquatic Toxicology·Volodymyr I Lushchak
Feb 1, 2003·Environmental Toxicology and Pharmacology·Ron van der OostNico P E Vermeulen
Nov 11, 2011·International Journal of Molecular Sciences·Aaron K HolleyDaret K St Clair
May 16, 2012·Chemosphere·Cleoni dos Santos CarvalhoMarisa Narciso Fernandes
Jul 7, 2012·Environmental Science and Pollution Research International·Hana PaskerováLuděk Bláha
Aug 27, 2013·Nature Genetics·Robert P MasonFlaviano Giorgini

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Citations

May 18, 2017·Environmental Science and Pollution Research International·Ewa JaszczakJacek Namieśnik
Feb 24, 2021·Environmental Science and Pollution Research International·Andrés Maximiliano AttademoMaría Rosa Repetti

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