In vivo study of experimental pneumococcal meningitis using magnetic resonance imaging

BMC Medical Imaging
Christian T BrandtIan J Rowland

Abstract

Magnetic Resonance Imaging (MRI) methods were evaluated as a tool for the study of experimental meningitis. The identification and characterisation of pathophysiological parameters that vary during the course of the disease could be used as markers for future studies of new treatment strategies. Rats infected intracisternally with S. pneumoniae (n = 29) or saline (n = 13) were randomized for imaging at 6, 12, 24, 30, 36, 42 or 48 hours after infection. T1W, T2W, quantitative diffusion, and post contrast T1W images were acquired at 4.7 T. Dynamic MRI (dMRI) was used to evaluate blood-brain-barrier (BBB) permeability and to obtain a measure of cerebral and muscle perfusion. Clinical- and motor scores, bacterial counts in CSF and blood, and WBC counts in CSF were measured. MR images and dMRI revealed the development of a highly significant increase in BBB permeability (P < 0.002) and ventricle size (P < 0.0001) among infected rats. Clinical disease severity was closely related to ventricle expansion (P = 0.024). Changes in brain water distribution, assessed by ADC, and categorization of brain 'perfusion' by cortex DeltaSI(bolus) were subject to increased inter-rat variation as the disease progressed, but without overall difference...Continue Reading

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Citations

Jan 5, 2010·BMC Infectious Diseases·Christian ØstergaardChristian T Brandt
Nov 9, 2010·Cerebrospinal Fluid Research·Anders D SkjoldingMarianne Juhler
Jan 5, 2008·The Journal of Infectious Diseases·Christian T BrandtIan J Rowland
May 5, 2009·Médecine et maladies infectieuses·B Mourvillier
Jan 20, 2009·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·Eddie Y-K Ng, Rajendra U Acharya
Aug 26, 2015·BMC Infectious Diseases·Janni L SporrbornChristian T Brandt
Feb 14, 2014·Journal of Neuroscience Methods·Maria UldallRigmor Jensen
Nov 22, 2013·Journal of Pharmaceutical and Biomedical Analysis·Verena Hoerr, Cornelius Faber
Dec 18, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·So Yoon AhnWon Soon Park

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