In vivo study of novelly formulated porcine-derived fibrinogen as an efficient sealant

Journal of Materials Science. Materials in Medicine
Zhang LiuHongbing He

Abstract

Fibrinogen has been used as surgical sealant in the clinical setting for decades. The application of human plasma-derived fibrinogen is limited due to high cost and the risk of prion and virus infection. We developed a novel arginine-formulated fibrinogen from cryoprecipitates of porcine plasma. This porcine-derived fibrinogen exhibited excellent stability during sterilization and better hemostatic efficacy than a leading commercial hemostatic product in a nonlethal hemorrhage model. Therefore, it has the potential to be more economical and readily available while having a decreased risk of human blood-borne pathogen transmission.

References

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Citations

Apr 12, 2018·Cell Transplantation·Sen-Lu ChenYu-Chi Wang
Mar 27, 2018·Bio-medical Materials and Engineering·Chenghu LiuYanping Shi

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