PMID: 9637354Jun 24, 1998Paper

In vivo study on the immunomodulating effects of OM-85 BV on survival, inflammatory cell recruitment and bacterial clearance in Klebsiella pneumonia

International Journal of Immunopharmacology
E Broug-Holub, G Kraal

Abstract

Oral administration of the bacterial extract OM-85 BV has been shown to prime alveolar macrophages (AM) in such a way that they secrete significantly more nitric oxide, tumor necrosis factor-alpha and interleukin-1beta upon in vitro stimulation with lipopolysaccharide (LPS). As increased cytokine secretion by AM may account for the therapeutic effect of OM-85 BV in respiratory tract infections, we studied the effect of orally administered OM-85 BV on the outcome of Klebsiella pneumoniae-induced pneumonia. Mice received a daily oral dose of OM-85 BV (350 mg/kg body weight) for 5 days and were intratracheally infected with 333, 1000 or 3333 CFU K. pneumoniae on day 8. It was shown that OM-85 BV pretreatment of mice has no effect on bacterial clearance, neutrophil recruitment and survival in this acute respiratory tract infection. Also, OM-85 BV treatment had no protective effect in a recurrent infection with K. pneumoniae. It is concluded that AM activation by oral treatment with OM-85 BV is not sufficient to play a protective role in respiratory tract infection with K. pneumoniae.

References

Jul 1, 1992·International Journal of Immunopharmacology·J DuchowM Goldman
Jan 1, 1992·Respiration; International Review of Thoracic Diseases·A MarchantM Goldman
Feb 11, 1991·Current Opinion in Immunology·C F Nathan, J B Hibbs
Dec 1, 1990·The Journal of Clinical Investigation·T J StandifordR M Strieter
Jan 1, 1989·Immunopharmacology and Immunotoxicology·J WybranL Schandene
Jan 1, 1994·Respiration; International Review of Thoracic Diseases·J Mauël

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Citations

Mar 13, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Hong LuanYongman Lv

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