In Vivo Subacute Toxicity and Antidiabetic Effect of Aqueous Extract of Nigella sativa

Evidence-based Complementary and Alternative Medicine : ECAM
Karima Bensiameur-TouatiSouhila Aouichat-Bouguerra

Abstract

Context. Nigella sativa seeds are usually used as traditional medicine for a wide range of therapeutic purposes. Objective. To investigate the subacute toxicity of NS aqueous extract and select its lowest dose to study its antidiabetic effect. Methods. 5 AqE.NS doses (2, 6.4, 21, 33, and 60 g/Kg) were daily administered to mice by gavage. Biochemical parameters measurements and histological study of the liver and the kidney were performed after 6 weeks of supplementation. Thereafter, and after inducing diabetes by alloxan, rats were treated by 2 g/Kg of AqE.NS during 8 weeks. Metabolic parameters were measured on sera. A horizontal electrophoresis of plasmatic lipoprotein was conducted. Glycogen, total lipids, and triglycerides were measured in the liver. TBARS were evaluated on adipose tissue, liver, and pancreas. Results. AqE.NS showed no variation in urea and albumin at the 5 doses, but hepatotoxicity from 21 g/Kg was confirmed by histopathological observations of the liver. In diabetic rats, AqE.NS significantly decreased glycemia, TG, T-cholesterol, LDL-c, and TBARS and showed a restored insulinemia and a significant increase in HDL-c. Results on the liver indicated a decrease in lipids and a possible glycogenogenesis. Con...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Apr 1, 1976·Biochemical Medicine·K Yagi
Mar 1, 1991·Journal of Ethnopharmacology·K H TennekoonE H Karunanayake
Nov 1, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·K KawakamiT Murase
Jun 1, 1988·Diabetologia·S Lenzen, U Panten
May 1, 1995·The American Journal of Medicine·A GriesmacherG Schernthaner
Aug 1, 1993·Planta medica·M Concepción NavarroM Pilar Utrilla
Jul 17, 1999·International Journal of Immunopharmacology·A HaqS T Al-Sedairy
Jun 27, 2000·Diabetes Care·M E HartnettD Armstrong
Dec 18, 2001·Journal of Ethnopharmacology·A ZaouiM Hassar
Apr 2, 2002·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·A ZaouiM Hassar
Jul 10, 2004·Annales pharmaceutiques françaises·D Bonnefont-RousselotJ Delattre
Oct 16, 2004·Fundamental & Clinical Pharmacology·Halima RchidYves Sauvaire
Nov 9, 2005·International Immunopharmacology·Mohamed Labib Salem
Mar 30, 2010·Regulatory Toxicology and Pharmacology : RTP·Jadwiga Jodynis-LiebertJuliusz Pernak
Apr 28, 2010·Archives of Pharmacal Research·Manar A NaderGhada M Suddek
Jul 26, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Tao Liu, Cui-Ping Yu
Mar 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Xin-Fang LeongKamsiah Jaarin
Apr 10, 2013·Asian Pacific Journal of Tropical Biomedicine·D K PatelS Hemalatha
May 7, 2013·Asian Pacific Journal of Tropical Biomedicine·Aftab AhmadFiroz Anwar
Jul 16, 2013·Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry·Amina Hamed Ahmad Alobaidi
Mar 19, 2014·Pharmaceutical Biology·Michael J HaasArshag D Mooradian
Jul 3, 2015·Journal of Endocrinological Investigation·S AsgaryN Goli-Malekabadi
Dec 9, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zeba FarooquiFarah Khan

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
MDA
light microscopy
optic microscopy

Software Mentioned

R Commander R

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

© 2022 Meta ULC. All rights reserved