In vivo super-resolution imaging of transient retinal phototropism evoked by oblique light stimulation

Journal of Biomedical Optics
Yiming LuXincheng Yao

Abstract

Rod-dominated transient retinal phototropism (TRP) has been observed in freshly isolated retinas, promising a noninvasive biomarker for objective assessment of retinal physiology. However, in vivo mapping of TRP is challenging due to its subcellular signal magnitude and fast time course. We report here a virtually structured detection-based super-resolution ophthalmoscope to achieve subcellular spatial resolution and millisecond temporal resolution for in vivo imaging of TRP. Spatiotemporal properties of in vivo TRP were characterized corresponding to variable light intensity stimuli, confirming that TRP is tightly correlated with early stages of phototransduction.

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Sep 19, 2009·Japanese Journal of Ophthalmology·Xin-Cheng Yao
Nov 15, 2012·Investigative Ophthalmology & Visual Science·Qiu-Xiang ZhangXin-Cheng Yao
Oct 30, 2013·Journal of Biomedical Optics·Rongwen LuXincheng Yao
Mar 24, 2015·Biomedical Optics Express·Daniel J FechtigRainer A Leitgeb
Sep 26, 2015·Journal of Biomedical Optics·Xincheng Yao, Benquan Wang
Jun 24, 2016·Journal of Biomedical Optics·Xiaohui ZhaoXincheng Yao
Sep 23, 2016·Journal of Biomedical Optics·Benquan WangXincheng Yao
Dec 20, 2016·Journal of Biomedical Optics·Changgeng LiuXincheng Yao

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Citations

Jun 20, 2020·Experimental Biology and Medicine·Xincheng Yao, Tae-Hoon Kim
Nov 30, 2018·Experimental Biology and Medicine·Xincheng YaoYiming Lu
Jan 9, 2019·Translational Vision Science & Technology·Yiming LuXincheng Yao

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