In vivo suppression of NK cell cytotoxicity by stress and surgery: glucocorticoids have a minor role compared to catecholamines and prostaglandins

Brain, Behavior, and Immunity
Ella RosenneS Ben-Eliyahu

Abstract

Most in vitro and ex-vivo studies indicate a profound suppression of NK cell cytotoxicity (NKCC) by glucocorticoids; while catecholamines and prostaglandins were reported both to suppress and to enhance NKCC. However, methodological considerations hinder our ability to deduce from these findings to the impact of endogenous release of these factors on in vivo levels of NKCC and their implications to NK-dependent resistance to pathologies in living humans or animals. Here we used an in vivo approach that sensitively and specifically reflects NKCC in living F344 rats, based on lung clearance of NK-sensitive tumor cells (MADB106), and based on comparing effects between NK-intact and NK-depleted rats. To study the role of corticosterone, epinephrine, and prostaglandins, we administered these factors to rats, or antagonized their endogenous release following different stress paradigms or surgery. The results indicated that endogenous or exogenous elevated corticosterone levels can suppress in vivo NKCC levels, but only under some conditions, and mostly secondarily to the NK-suppressing impact of epinephrine. Specifically, corticosterone-induced NKCC suppression occurred (i) only under prolonged, but not short exposure to stress, and ...Continue Reading

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Citations

Oct 11, 2015·International Journal of Cancer. Journal International Du Cancer·Pini MatznerShamgar Ben-Eliyahu
Sep 1, 2015·Frontiers in Pharmacology·Angela Scanzano, Marco Cosentino
Mar 31, 2015·The Cancer Journal·Elizabeth A RepaskyBonnie L Hylander
Jan 21, 2015·Nature Reviews. Clinical Oncology·Maya HorowitzShamgar Ben-Eliyahu
Mar 5, 2015·International Immunopharmacology·P A SarapultsevA P Sarapultsev
Sep 14, 2016·International Anesthesiology Clinics·Itay RiconShamgar Ben-Eliyahu
Mar 29, 2019·PLoS Biology·Amit BenbenishtyPablo Blinder
Sep 5, 2018·Journal for Immunotherapy of Cancer·Orneala BakosLee-Hwa Tai
Aug 18, 2017·JCI Insight·Archana S NagarajaAnil K Sood
Jun 7, 2020·Cellular & Molecular Immunology·Silvia CapellinoCarsten Watzl
Sep 4, 2019·Molecular Cancer·Zhiwei ChenShengtao Zhou
Nov 22, 2020·Seminars in Immunopathology·Akihiro Shimba, Koichi Ikuta
Nov 18, 2017·Cancer Immunology Research·Michael D NissenStephen R Mattarollo
Dec 28, 2019·Brain, Behavior, and Immunity·Annina SeilerChristopher P Fagundes
Dec 6, 2014·The Journal of Surgical Research·Maria F RamirezJuan P Cata
Jun 30, 2021·Annals of the New York Academy of Sciences·Francisco Stefânio BarretoDanielle S Macedo
Jul 24, 2021·BJPsych Advances·Anurag K SinghUriel Halbreich
Sep 12, 2021·Nature Reviews. Cancer·Anabel EckerlingShamgar Ben-Eliyahu

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