In vivo surgical resection plus adjuvant gene therapy in the treatment of mammary and prostate cancer

Molecular Therapy : the Journal of the American Society of Gene Therapy
S W SukinEstuardo Aguilar-Cordova

Abstract

Adenoviral-mediated gene therapy delivery, combining the herpes simplex virus thymidine kinase gene (Ad-tk) with gancyclovir, has been evaluated as a treatment modality for numerous tumors in the laboratory and in the clinics. As a single modality, gene therapy has shown some promising local and systemic results but no curative success. Surgery is the standard of care for many solid tumors. However, minor residual tumor following surgical resection can lead to local recurrence, and surgery is neither efficient nor plausible for metastatic disease. In this study, two tumor models were used to evaluate the effects of Ad-tk gene therapy as an adjuvant to surgery. Subcutaneous mammary- and prostate-derived tumors were produced in syngeneic mice. To evaluate systemic effects, tumor cells were injected intravenously, with subsequent formation of lung nodules. The subcutaneous tumors were surgically resected and the tumor bed was bathed with saline or Ad-tk. The animals were evaluated for toxicity, local tumor recurrence, survival, and lung nodule formation. No evidence of additional toxicity was observed. In the less aggressive mammary model, the time to recurrence was increased from 11.7 (+/-1.0) days to 22.7 (+/-5.5) days. In the p...Continue Reading

References

May 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·P A BaleyT C Thompson
May 15, 1995·International Journal of Radiation Oncology, Biology, Physics·G K ZagarsA C von Eschenbach
Jun 2, 1993·Journal of the National Cancer Institute·E J FeuerT Tong
Jan 1, 1997·CA: a Cancer Journal for Clinicians·S L ParkerP A Wingo
Jul 1, 1997·Nature Medicine·C Nyberg-HoffmanE Aguilar-Cordova
Oct 23, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J A EasthamS P Lerner
Feb 5, 1998·CA: a Cancer Journal for Clinicians·S H LandisP A Wingo
May 26, 1999·Human Gene Therapy·J R HermanP T Scardino
Apr 25, 2000·American Journal of Surgery·P I TartterD Zapetti

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Citations

Aug 17, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E Antonio ChioccaPamela Z New
Apr 6, 2011·Journal of Cellular Biochemistry·Laura K AguilarEstuardo Aguilar-Cordova
Mar 22, 2015·Cancer Immunology, Immunotherapy : CII·Laura K AguilarMark Bloomston
Feb 17, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Gustavo AyalaDov Kadmon
Jan 27, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Alejandra Miranda-DíazJuan Armendáriz-Borunda

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