In vivo switching of human melanoma cells between proliferative and invasive states

Cancer Research
Keith S HoekReinhard Dummer


Metastatic melanoma represents a complex and heterogeneous disease for which there are no therapies to improve patient survival. Recent expression profiling of melanoma cell lines identified two transcription signatures, respectively, corresponding with proliferative and invasive cellular phenotypes. A model derived from these findings predicts that in vivo melanoma cells may switch between these states. Here, DNA microarray-characterized cell lines were subjected to in vitro characterization before s.c. injection into immunocompromised mice. Tumor growth rates were measured and postexcision samples were assessed by immunohistochemistry to identify invasive and proliferative signature cells. In vitro tests showed that proliferative signature melanoma cells are faster growing but less motile than invasive signature cells. In vivo proliferative signature cells initiated tumor growth in 14 +/- 3 days postinjection. By comparison, invasive signature cells required a significantly longer (P < 0.001) period of 59 +/- 11 days. Immunohistochemistry showed that regardless of the seed cell signature, tumors showed evidence for both proliferative and invasive cell types. Furthermore, proliferative signature cell types were detected most f...Continue Reading


Apr 1, 1978·Annals of Surgery·A Breslow
Jan 1, 1988·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·N BraunH K Müller-Hermelink
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A B RobertsM B Sporn
Feb 1, 1980·Journal of Clinical Pathology·A Levene
May 3, 2000·Histopathology·S S Banerjee, M Harris
Aug 23, 2001·Current Biology : CB·A M Zorn
Nov 9, 2001·The Journal of Biological Chemistry·Jinyan Du, David E Fisher
Dec 3, 2002·FEBS Letters·Hidetoshi HasuwaMasaru Okabe
Dec 1, 2004·Annual Review of Genetics·Eiríkur SteingrímssonNancy A Jenkins
Dec 30, 2004·The Journal of Cell Biology·Amy E LoercherJ William Harbour
Apr 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Christopher HaqqMohammed Kashani-Sabet
Aug 23, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Okay SaydamCornel Fraefel
Nov 18, 2005·The New England Journal of Medicine·John A CurtinBoris C Bastian
Jan 7, 2006·Nature Reviews. Cancer·Karin E de VisserLisa M Coussens
Mar 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Paul M KulesaMary J C Hendrix
Mar 28, 2006·Journal of Cellular and Molecular Medicine·Elisabeth A SeftorMary J C Hendrix
Jul 11, 2006·The New England Journal of Medicine·Arlo J Miller, Martin C Mihm
Aug 8, 2006·Nature Medicine·Jolanta M TopczewskaMary J C Hendrix
Dec 14, 2006·Advances in Experimental Medicine and Biology·Linda HolmquistSven Påhlman
Dec 22, 2006·Genes & Development·Suzanne CarreiraColin R Goding
Dec 28, 2006·Clinical and Experimental Medicine·D RibattiA Vacca
Jan 27, 2007·The Cochrane Database of Systematic Reviews·A D SasseO A C Clark
Feb 3, 2007·Biochemical and Biophysical Research Communications·Fatima LekmineGeorge I Salti

❮ Previous
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Aug 22, 2013·Cancer Letters·Chonglin LuoStefan B Eichmüller
Mar 29, 2013·Nature Reviews. Cancer·Michael HölzelThomas Tüting
Jan 13, 2011·Nature Reviews. Molecular Cell Biology·Berend Snijder, Lucas Pelkmans
May 18, 2011·Oncogene·I ArozarenaC Wellbrock
Jun 14, 2012·Carcinogenesis·Miguel F SeguraEva Hernando
Feb 10, 2012·Current Opinion in Oncology·Reinhard Dummer, Keith T Flaherty
Dec 11, 2008·Pigment Cell & Melanoma Research·Keith S HoekEirikur Steingrimsson
Nov 6, 2008·Pigment Cell & Melanoma Research·Anthony L Cook, Richard A Sturm
Jan 15, 2009·Pigment Cell & Melanoma Research·Keith S HoekReinhard Dummer
Apr 17, 2009·Pigment Cell & Melanoma Research·Natalie C SchlegelKeith S Hoek
Aug 28, 2009·Pigment Cell & Melanoma Research·Michael P O'Connell, Ashani T Weeraratna
Oct 22, 2009·Pigment Cell & Melanoma Research·Liliana Ossowski, Julio A Aguirre-Ghiso
Nov 10, 2009·Pigment Cell & Melanoma Research·Aline PrimotMarie-Dominique Galibert
May 7, 2010·Pigment Cell & Melanoma Research·Melissa L HarrisWilliam J Pavan
Aug 24, 2010·Pigment Cell & Melanoma Research·Keith S Hoek, Colin R Goding
Nov 23, 2010·Pigment Cell & Melanoma Research·Perrine Pinon, Bernhard Wehrle-Haller
Apr 26, 2011·Pigment Cell & Melanoma Research·Keith S Hoek
Dec 24, 2010·Pigment Cell & Melanoma Research·Marie C ZipserKeith S Hoek
Mar 26, 2011·Pigment Cell & Melanoma Research·Glen M BoyleNicholas K Hayward
Oct 8, 2011·Pigment Cell & Melanoma Research·M P O'Connell, A T Weeraratna
Mar 28, 2013·Science Signaling·Marie R Webster, Ashani T Weeraratna
Sep 19, 2012·Molecular and Cellular Biology·Elise BonvinColin R Goding
Jan 8, 2011·Cancer Research·Natasha Y FrankMarkus H Frank
Jan 7, 2010·The Journal of Clinical Investigation·Natasha Y FrankMarkus H Frank
Feb 17, 2009·BMC Cancer·Andreas WinklmeierAnja K Bosserhoff
Oct 16, 2009·Journal of Translational Medicine·Giuseppe PalmieriPaolo A Ascierto
Dec 31, 2009·PloS One·Aaron R JeffsMichael R Eccles
Mar 24, 2012·PloS One·Daniela Mihic-ProbstReinhard Dummer
Jan 24, 2013·PloS One·Christian BuschUlrich Drews
Sep 17, 2013·PloS One·Christiane MargueStephanie Kreis
Feb 19, 2013·Future Oncology·Dana Koludrovic, Irwin Davidson
May 8, 2013·Future Oncology·Ewa AladowiczLuisa Lanfrancone
Jan 31, 2014·Cellular and Molecular Life Sciences : CMLS·José A MartinaRosa Puertollano
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