In vivo terahertz imaging of rat skin burns

Journal of Biomedical Optics
Priyamvada TewariZachary D Taylor

Abstract

A reflective, pulsed terahertz (THz) imaging system was used to acquire high-resolution (d(10-90)/λ~1.925) images of deep, partial thickness burns in a live rat. The rat's abdomen was burned with a brass brand heated to ~220°C and pressed against the skin with contact pressure for ~10 sec. The burn injury was imaged beneath a Mylar window every 15 to 30 min for up to 7 h. Initial images display an increase in local water concentration of the burned skin as evidenced by a marked increase in THz reflectivity, and this likely correlates to the post-injury inflammatory response. After ~1 h the area of increased reflectivity consolidated to the region of skin that had direct contact with the brand. Additionally, a low reflecting ring of tissue could be observed surrounding the highly reflective burned tissue. We hypothesize that these regions of increased and decreased reflectivity correlate to the zones of coagulation and stasis that are the classic foundation of burn wound histopathology. While further investigations are necessary to confirm this hypothesis, if true, it likely represents the first in vivo THz images of these pathologic zones and may represent a significant step forward in clinical application of THz technology.

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Citations

Oct 23, 2012·Journal of Biomedical Optics·David BennettElliott Brown
Sep 1, 2015·IEEE Transactions on Terahertz Science and Technology·Zachary D TaylorWarren S Grundfest
Jul 15, 2015·IEEE Transactions on Terahertz Science and Technology·Zachary D TaylorWarren S Grundfest
Jul 24, 2014·IEEE Journal of Biomedical and Health Informatics·Caroline B ReidVincent P Wallace
Sep 8, 2016·Advances in Wound Care·Moumita DuttaRuyan Guo
May 22, 2016·Trends in Biotechnology·Xiang YangYang Luo
Feb 7, 2017·Scientific Reports·G G Hernandez-CardosoE Castro-Camus
Jan 20, 2017·Biomedical Optics Express·Neha BajwaZachary D Taylor
Nov 3, 2016·Journal of Biophotonics·Shuting FanEmma Pickwell-MacPherson
Feb 1, 2017·IEEE Transactions on Bio-medical Engineering·Neha BajwaZachary D Taylor
Jul 14, 2016·Journal of Biomedical Optics·Rui ZhangJing Fang
Feb 9, 2020·Sensors·Amani Yousef OwdaNacer-Ddine Rezgui
Feb 19, 2019·Biomedical Optics Express·Priyamvada TewariZachary Taylor
Apr 29, 2020·Biomedical Optics Express·Junliang DongRoberto Morandotti
Sep 26, 2015·Optics Express·Tzu-Fang TsengChi-Kuang Sun
Jul 2, 2019·Biomedical Optics Express·Xomalin G PeraltaIbtissam Echchgadda
Dec 8, 2020·Biomedical Optics Express·Omar B OsmanM Hassan Arbab

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