In vivo testing of nanoparticle-treated TTCP/DCPA-based ceramic surfaces

Acta Biomaterialia
Wen-Cheng ChenJiin-Huey Chern Lin

Abstract

This study reports the development of a non-dispersive calcium phosphate cement (nd-CPC) paste containing tetracalcium phosphate and anhydrous dicalcium phosphate that can be used as a filling material in dental and orthopedic applications. The nd-CPC bone cement is compared with two commercial materials, OsteoSet and Collagraft bone grafts. Gross examination of retrieved implants/bone composite samples indicated that none of the implants in this study evoked an inflammatory response. The OsteoSet (calcium sulfate) implant was resorbed too quickly to allow for osteo-remodeling, and it led to the formation of fibrous connective tissue in the fracture site, which remained even 24 weeks after implantation. Histological examination revealed that nd-CPC and Collagraft (hydroxyapatite/tricalcium phosphate/collagen) had greater remodeling and osteoconductive activity than OsteoSet at both 12 and 24 weeks after implantation. Greater remodeling activities were found with nd-CPC cement than with the other materials at 12 weeks after implantation, and the Fourier transform infrared absorption band of carbonate or cellulose derivatives grew from 6 weeks to 24 weeks after implantation in nd-CPC cement. These findings show that nd-CPC compar...Continue Reading

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Citations

Apr 12, 2011·Journal of Materials Science. Materials in Medicine·M Anirban Jyoti, Ho-Yeon Song
May 28, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Chia-Ling KoJen-Chyan Wang
Mar 4, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Wei-Luen ChenJiin-Huey Chern Lin
Nov 22, 2011·Journal of Dentistry·Jian-Chih ChenWen-Cheng Chen
Aug 7, 2010·Acta Biomaterialia·Johan Van der StokPeter Patka
Mar 19, 2014·Journal of Biomedical Materials Research. Part a·Chia-Ling KoWen-Cheng Chen
Jan 31, 2012·Bioinorganic Chemistry and Applications·Fu-Yuan TengWen-Cheng Chen
Aug 12, 2016·Journal of Biomaterials Applications·Byung-Hyun LeeYong-Keun Lee

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