PMID: 6405386May 1, 1983Paper

In vivo therapy with monoclonal anti-I-A antibody suppresses immune responses to acetylcholine receptor

Proceedings of the National Academy of Sciences of the United States of America
M K WaldorL Steinman

Abstract

A monoclonal antibody to I-A gene products of the immune response gene complex attenuates both humoral and cellular responses to acetylcholine receptor and appears to suppress clinical manifestations of experimental autoimmune myasthenia gravis. This demonstrates that use of antibodies against immune response gene products that are associated with susceptibility to disease may be feasible for therapy in autoimmune conditions such as myasthenia gravis.

References

Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S HeinemannJ Rice
Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·M I GreeneB Benacerraf
Jan 1, 1977·Arthritis and Rheumatism·J D GabourelG H Davies
Aug 1, 1978·Tissue Antigens·J SäfwenbergC I Smith
Nov 24, 1977·The New England Journal of Medicine·P C DauL E Spitler
Apr 1, 1973·Analytical Biochemistry·J Schmidt, M A Raftery
Aug 1, 1982·The Journal of Experimental Medicine·L L Perry, M I Greene
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·D MerueloH O McDevitt
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·L SteinmanH O McDevitt
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S J TzartosJ M Lindstrom
Jan 1, 1980·The Journal of Experimental Medicine·P W Berman, J Patrick
Jul 1, 1980·Muscle & Nerve·N L NorcrossJ A Lettieri

❮ Previous
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Citations

Dec 1, 1986·Agents and Actions·M F van den BroekL B van de Putte
Feb 1, 1985·European Journal of Clinical Microbiology·H Krakauer
Jan 1, 1995·Folia Microbiologica·B Ríhová
Jul 7, 2009·Archivum Immunologiae Et Therapiae Experimentalis·Sek C Chow
Dec 27, 1985·Journal of Immunological Methods·I R Williams, L L Perry
Dec 1, 1988·Journal of the Neurological Sciences·E M FrohmanS van den Noort
Apr 1, 1993·Journal of the Neurological Sciences·J R OksenbergL Steinman
May 1, 1988·Journal of Neuroimmunology·M HayashiS Shiga
Jun 1, 1991·Research in Immunology·C BoitardJ F Bach
Jul 1, 1996·Research in Immunology·H AmitalY Shoenfeld
Nov 25, 2003·Current Opinion in Immunology·William H RobinsonLawrence Steinman
Oct 3, 1999·Veterinary Immunology and Immunopathology·G D Shelton
Feb 1, 1985·Journal of Neuroimmunology·G H WongJ W Schrader
Dec 1, 1990·Baillière's Clinical Rheumatology·B Kirkham, G S Panayi
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M K WaldorL A Herzenberg
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C BoitardH O McDevitt
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C BoitardJ F Bach
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·E ZismanE Mozes
Oct 1, 1983·The Journal of Experimental Medicine·N E AdelmanH O McDevitt
Oct 1, 1983·The Journal of Experimental Medicine·S Sriram, L Steinman
Feb 1, 1985·The Journal of Experimental Medicine·D Wofsy, W E Seaman
May 1, 1988·The Journal of Experimental Medicine·S S ZamvilH Acha-Orbea
Aug 1, 1996·The Journal of Experimental Medicine·G X ZhangT Olsson
Oct 1, 1992·American Journal of Reproductive Immunology : AJRI·J L NelsonJ A Hansen
Jun 21, 1993·Annals of the New York Academy of Sciences·L MoiolaB M Conti-Tronconi
Jun 21, 1993·Annals of the New York Academy of Sciences·D B DrachmanL Balcer
Jul 21, 1998·Annals of the New York Academy of Sciences·B M Conti-FineZ Y Wang
Jul 1, 1988·Postgraduate Medical Journal·I R Mackay, M J Rowley
Jan 1, 1989·Journal of Clinical Immunology·E M FrohmanS Gupta

❮ Previous
Next ❯

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