Myelinating oligodendrocytes arise from migratory and proliferative oligodendrocyte progenitor cells (OPCs). Complete myelination requires that oligodendrocytes be uniformly distributed and form numerous, periodically spaced membrane sheaths along the entire length of target axons. Mechanisms that determine spacing of oligodendrocytes and their myelinating processes are not known. Using in vivo time-lapse confocal microscopy, we show that zebrafish OPCs continuously extend and retract numerous filopodium-like processes as they migrate and settle into their final positions. Process remodeling and migration paths are highly variable and seem to be influenced by contact with neighboring OPCs. After laser ablation of oligodendrocyte-lineage cells, nearby OPCs divide more frequently, orient processes toward the ablated cells and migrate to fill the unoccupied space. Thus, process activity before axon wrapping might serve as a surveillance mechanism by which OPCs determine the presence or absence of nearby oligodendrocyte-lineage cells, facilitating uniform spacing of oligodendrocytes and complete myelination.
Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor cell
Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture
In vivo proliferation of oligodendrocyte progenitors expressing PDGFalphaR during early remyelination
Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis
Activation and proliferation of endogenous oligodendrocyte precursor cells during ethidium bromide-induced demyelination
Platelet-derived growth factor-alpha receptor-positive oligodendroglia are frequent in multiple sclerosis lesions
A role for the polysialic acid-neural cell adhesion molecule in PDGF-induced chemotaxis of oligodendrocyte precursor cells
Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling
Growth conelike sensorimotor structures are characteristic features of postmigratory, premyelinating oligodendrocytes
Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage
Cell proliferation and cytoarchitectural remodeling during spinal cord reconnection in the fresh-water turtle Trachemys dorbignyi.
Phylogeny of proteolipid proteins: divergence, constraints, and the evolution of novel functions in myelination and neuroprotection
nkx2.2a promotes specification and differentiation of a myelinating subset of oligodendrocyte lineage cells in zebrafish.
APC/C(Fzr/Cdh1)-dependent regulation of cell adhesion controls glial migration in the Drosophila PNS
Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain
From fish to man: understanding endogenous remyelination in central nervous system demyelinating diseases.
Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene
Multiple conserved regulatory elements with overlapping functions determine Sox10 expression in mouse embryogenesis
An evolutionarily conserved intronic region controls the spatiotemporal expression of the transcription factor Sox10
Sox10-Venus mice: a new tool for real-time labeling of neural crest lineage cells and oligodendrocytes
Brother of cdo (umleitung) is cell-autonomously required for Hedgehog-mediated ventral CNS patterning in the zebrafish
Fluorescent transgenic zebrafish Tg(nkx2.2a:mEGFP) provides a highly sensitive monitoring tool for neurotoxins
A selective glial barrier at motor axon exit points prevents oligodendrocyte migration from the spinal cord.
FluoroMyelin™ Red is a bright, photostable and non-toxic fluorescent stain for live imaging of myelin.
Possible roles of Plexin-A4 in positioning of oligodendrocyte precursor cells in developing cerebral cortex
Adult Stem Cells
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This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.