In vivo toxic effects of halothane on canine cerebral metabolic pathways.

The American Journal of Physiology
J D Michenfelder, R A Theye

Abstract

The effects of high concentrations of halothane on cerebral metabolism were examined in dogs with the aid of an extracorporeal circuit to support the systemic circulation. At blood levels exceeding those representing equilibration with 2.3% halothane, a dose-related decrease in cerebral oxygen consumption (CMR02) occurred that was unrelated to the presence or absence of an active electroencephalogram. In this circumstance, despite adequate oxygen delivery, a dose-related alteration in oxidative phosphorylation also occurred as evidenced by progressive decreases in cerebral concentrations of ATP and phosphocreatine and concomitant increases in cerebral lactate and lactate/pyruvate ratio. These effects were totally reversible, except for persistence of increased of increased CMR02, after return to low halothane concentrations. It is concluded that the mechanisms of the cerebral metabolic effects of halothane differ from those of thiopental and, at high concentrations, are at least in part related to interference with oxidative phosphorylation. These in vivo studies confirm the potentially detrimental effects of high halothane concentrations on cerebral metabolic pathways as demonstrated by others in vitro.

Citations

Jan 1, 1982·Acta Anaesthesiologica Scandinavica. Supplementum·P A Steen
Sep 1, 1980·Stroke; a Journal of Cerebral Circulation·A TamuraK Sano
Mar 21, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F HyderD Rothman
Apr 20, 2002·Anesthesiology·Joseph F AntogniniRichard Atherley
Feb 28, 2004·The Journal of Biological Chemistry·Jin XiRoderic G Eckenhoff
Jan 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M JacewiczW A Pulsinelli
Jun 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L LittT L James
Apr 29, 2006·Acta Anaesthesiologica Scandinavica·R BainsM L Vinje
Jun 1, 1978·Journal of Neurochemistry·S C Cheng, E A Brunner
Mar 1, 1980·Anaesthesia·M Belopavlovic, A Buchthal
Sep 1, 1988·Neuroscience and Behavioral Physiology·A E KaasikM V Ul'st
Mar 1, 1982·Canadian Anaesthetists' Society Journal·J W McIntyre, J G Purdell-Lewis

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