In vivo toxicologic study of larger silica nanoparticles in mice

International Journal of Nanomedicine
Wai-Tao ChanShao-Yi Hou

Abstract

Silica nanoparticles (SiNPs) are being studied and used for medical purposes. As nanotechnology grows rapidly, its biosafety and toxicity have frequently raised concerns. However, diverse results have been reported about the safety of SiNPs; several studies reported that smaller particles might exhibit toxic effects to some cell lines, and larger particles of 100 nm were reported to be genotoxic to the cocultured cells. Here, we investigated the in vivo toxicity of SiNPs of 150 nm in various dosages via intravenous administration in mice. The mice were observed for 14 days before blood examination and histopathological assay. All the mice survived and behaved normally after the administration of nanoparticles. No significant weight change was noted. Blood examinations showed no definite systemic dysfunction of organ systems. Histopathological studies of vital organs confirmed no SiNP-related adverse effects. We concluded that 150 nm SiNPs were biocompatible and safe for in vivo use in mice.

Citations

Mar 14, 2018·International Journal of Molecular Sciences·Ilzira A MinigalievaEkaterina Y Meshtcheryakova
Oct 9, 2019·Nature Communications·Zhen ZhangYong Zhang
Mar 30, 2019·Nanoscale Research Letters·Valeria De MatteisRosaria Rinaldi
Sep 17, 2019·International Journal of Molecular Medicine·Ye YangZhongjun Du
Jan 17, 2018·EFSA Journal·UNKNOWN EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)Claude Lambré
Nov 25, 2020·Bulletin of Experimental Biology and Medicine·G Yu YukinaM M Galagudza
Dec 10, 2020·Journal of Hazardous Materials·Caixia GuoYanbo Li
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Aug 7, 2021·Scientific Reports·Sujata BuppSteven Kozlowski

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Methods Mentioned

BETA
dynamic light scattering

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SPSS

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