In vivo toxicological evaluation of graphene oxide nanoplatelets for clinical application

International Journal of Nanomedicine
Mohammad Amrollahi-SharifabadiAlexander M Seifalian

Abstract

Graphene is considered as a wonder material; it is the strongest material on the planet, super-elastic, and conductive. Its application in biomedicine is huge, with a multibillion-dollar industry, and will revolutionize the diagnostic and treatment of diseases. However, its safety and potential toxicity is the main challenge. This study assessed the potential toxicity of graphene oxide nanoplatelets (GONs) in an in vivo animal model using systemic, hematological, biochemical, and histopathological examinations. Normal saline (control group) or GONs (3-6 layers, lateral dimension=5-10 μm, and thickness=0.8-2 nm) at dose rate of 50, 150, or 500 mg/kg were intraperitoneally injected into adult male Wistar rats (n=5) every 48 hours during 1 week to receive each animal a total of four doses. The animals were allowed 2 weeks to recover after the last dosing. Then, animals were killed and the blood was collected for hematological and biochemical analysis. The organs including the liver, kidney, spleen, lung, intestine, brain, and heart were harvested for histopathological evaluations. The results showed GONs prevented body weight gain in animals after 21 days, treated at 500 mg/kg, but not in the animals treated at 150 or 50 mg/kg GON...Continue Reading

Citations

Nov 15, 2018·International Journal of Molecular Sciences·Chengzhu LiaoSie Chin Tjong
Nov 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rita PetrucciAnd Marta Feroci
Apr 3, 2020·Archives of Toxicology·Feng XiaoliShao Longquan
Jun 6, 2020·Nanotechnology·Xiaofeng DaiKostya Ken Ostrikov
Jul 8, 2020·Environmental Science and Pollution Research International·Naresh K NirmalPlacheril J John
Apr 26, 2020·International Journal of Molecular Sciences·Jia-Wei YangGuan-Yu Chen
Jul 31, 2020·Nanomaterials·Marta d'AmoraSilvia Giordani
Nov 19, 2019·Current Cancer Drug Targets·Agnieszka ZuchowskaZbigniew Brzozka
Dec 17, 2020·Frontiers in Microbiology·Mario F Gómez-NúñezAlberto N Peón
May 1, 2021·Nanomaterials·Pariya ZareAlexander M Seifalian

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Methods Mentioned

BETA
X-ray
scanning
transmission electron microscopy
lavage

Software Mentioned

GraphPad Prism
GraphPad

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