Abstract
Pulmonary delivery of therapeutics is attractive due to rapid absorption and non-invasiveness but it is challenging to monitor and quantify the delivered aerosol or powder. Currently, single-photon emission computed tomography (SPECT) is used but requires inhalation of radioactive labels that typically have to be synthesized and attached by hot chemistry techniques just prior to every scan. Methods: In this work, we demonstrate that superparamagnetic iron oxide nanoparticles (SPIONs) can be used to label and track aerosols in vivo with high sensitivity using an emerging medical imaging technique known as magnetic particle imaging (MPI). We perform proof-of-concept experiments with SPIONs for various lung applications such as evaluation of efficiency and uniformity of aerosol delivery, tracking of the initial aerosolized therapeutic deposition in vivo, and finally, sensitive visualization of the entire mucociliary clearance pathway from the lung up to the epiglottis and down the gastrointestinal tract to be excreted. Results: Imaging of SPIONs in the lung has previously been limited by difficulty of lung imaging with magnetic resonance imaging (MRI). In our results, MPI enabled SPION lung imaging with high sensitivity, and a key...Continue Reading
Citations
Jul 25, 2019·Journal of Magnetic Resonance Imaging : JMRI·Nazanin TaleblooPing Wang
Sep 4, 2019·Scientific Reports·Patrick VogelVolker C Behr
Sep 7, 2019·Nanotechnology·Kai WuJian-Ping Wang
Nov 26, 2019·Physics in Medicine and Biology·Zhiyuan ZhaoCarlos Rinaldi
Jan 7, 2020·Critical Reviews in Toxicology·A R KolliJ Hoeng
Feb 27, 2020·Chemical Communications : Chem Comm·Lucy GloagRichard D Tilley
Jun 9, 2019·Nanoscale Research Letters·Junwei ZhaoXin Wang
May 23, 2020·Physics in Medicine and Biology·Zhiyuan Zhao, Carlos Rinaldi
Feb 7, 2020·Scientific Reports·Hendrik PaysenFrank Wiekhorst
Nov 16, 2018·Nanomaterials·Paola Sánchez-MorenoHouria Boulaiz
Jul 19, 2019·Micromachines·Carmen J GilVahid Serpooshan
Oct 19, 2019·Nanomaterials·Harald KratzJörg Schnorr
Jun 12, 2018·The British Journal of Radiology·Prashant ChandrasekharanSteven Conolly
Jan 12, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Yao LuSteven Conolly
Dec 25, 2019·Chest·Hongbin WangXilin Sun
Oct 16, 2020·Scientific Reports·Azadeh MohtashamdolatshahiJörg Schnorr
May 1, 2021·Diagnostics·Xiaojun ChenXiaoying Tang
Apr 16, 2021·Annual Review of Chemical and Biomolecular Engineering·Angelie Rivera-Rodriguez, Carlos M Rinaldi-Ramos
Jul 21, 2021·Acta Biomaterialia·Zewei ZhuoHao Chen
Dec 24, 2019·ACS Nano·Zijian ZhouXiaoyuan Chen
Nov 10, 2020·ACS Applied Nano Materials·Julia GuzyErik M Shapiro
Dec 12, 2020·ACS Nano·Staffan HildebrandAlexander Pfeifer
Jan 12, 2022·Chemical Reviews·Shuren WangYanglong Hou
Jan 27, 2022·Nanoscale·Stanley Harvell-SmithNguyen Thi Kim Thanh