In vivo tracking of transfused platelets for recovery and survival studies: an appraisal of labeling methods

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
Pieter F van der MeerAnneke Brand

Abstract

The measurement of recovery and survival of platelets is an important decisive factor when 'new' platelet products have been developed. Recovery and survival measurements are mostly performed with radioactive-labeled platelets in healthy volunteers. This approach is required by the FDA for acceptance of platelet products that differ substantially in production or storage conditions from standard methods. However, due to regulatory obstacles, such radiolabeling studies are only carried out in designated institutes. Many countries do not require radioactive labeling studies in volunteers prior to accepting new products, and rather rely on surrogate tests. Also, the European guide to the preparation of blood components does not require this step. This paper reviews alternative, non-radioactive methods, which includes biotinylation of platelets, and discrimination of transfused platelets based on HLA discrepancy. The benefits and disadvantages of these methods will be discussed.

References

Aug 1, 1980·The British Journal of Radiology·O R van ReenenH Pieters
Dec 1, 1993·British Journal of Haematology·E HeilmannG L Dale
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·A D MichelsonC R Valeri
Sep 1, 1997·Current Opinion in Hematology·G L Dale
Feb 26, 1999·Transfusion·H CowleyJ L Miller
Oct 26, 1999·Transfusion·D G CordleD M Mock
May 25, 2002·Nuclear Medicine Communications·H LouwesE Vellenga
Jan 1, 1961·Proceedings of the Society for Experimental Biology and Medicine·T T ODELL, T P McDONALD
Dec 25, 2003·Transfusion·James P AuBuchonScott Murphy
Jun 10, 2005·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·C Robert ValeriGina Ragno
Jul 1, 2005·Transfusion·James P AuBuchonJill Roger
Aug 24, 2005·British Journal of Haematology·Darren L HughesLorna M Williamson
Nov 21, 2007·Hematology·Sherrill J Slichter
Jun 21, 2008·Radiology·Fred A MettlerMahadevappa Mahesh

❮ Previous
Next ❯

Citations

Oct 26, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Konstanze AurichWerner Weitschies
Mar 27, 2013·The American Journal of Tropical Medicine and Hygiene·Konstantin A TsetsarkinDana L Vanlandingham
Jan 11, 2020·The Journal of Small Animal Practice·P GantK Humm
Jan 17, 2021·International Journal of Molecular Sciences·Vincent Q SierMunitta Muthana
Aug 2, 2018·ACS Applied Materials & Interfaces·Thi-Huong NguyenKonstanze Aurich
May 13, 2019·ACS Biomaterials Science & Engineering·Manos GkikasBradley D Olsen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.