In vivo tumor lactate relaxation measurements by selective multiple-quantum-coherence (Sel-MQC) transfer

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Manickam MuruganandhamQ He

Abstract

The frequency-selective multiple-quantum-coherence (Sel-MQC) lactate (Lac) filter offers complete lipid and water suppression in a single scan for robust in vivo detection of tumor Lac, even in the presence of abundant lipids. Conversion of the detected signal into accurate tissue concentrations of Lac requires knowledge of in vivo Lac T1 and T2 relaxation times. This work reports modifications to the Sel-MQC pulse sequence, T1- and T2-Sel-MQC, that facilitate relaxation measurements of Lac. The T1-Sel-MQC sequence combines an inversion prepulse with the Sel-MQC filter. The T2-Sel-MQC sequence incorporates a CH3-selective 180 degrees pulse during the MQ preparation period to overcome the J-modulation effects and allow the insertion of variable echo delays. The performance of these sequences was evaluated with the use of phantoms and subcutaneous murine tumor models in vivo. The present approach will allow investigators to correct for the relaxation-induced Lac signal loss in Sel-MQC experiments for the quantitative mapping of in vivo tumor Lac distribution.

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Citations

Jun 15, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Philipp MörchelMichael Flentje
Sep 15, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gerd MelkusPeter M Jakob
Jun 16, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S B ThakurJ A Koutcher
Jul 31, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Stephen PickupJerry D Glickson
Oct 27, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·He ZhuQiuhong He
Mar 1, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Vincent O BoerDennis W J Klomp
Apr 25, 2015·Journal of Magnetic Resonance·Mirjam HolbachDieter Suter
Apr 8, 2014·Journal of Magnetic Resonance·Mirjam HolbachDieter Suter
Oct 31, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Qiuhong HeVeerle Ilse Julie Bossuyt
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