In Vivo Validation of Electrocardiographic Imaging

JACC. Clinical Electrophysiology
Matthijs J M CluitmansPaul G A Volders

Abstract

The purpose of this study was to evaluate the accuracy of noninvasive reconstructions of epicardial potentials, electrograms, activation and recovery isochrones, and beat origins by simultaneously performing electrocardiographic imaging (ECGI) and invasive epicardial electrography in intact animals. Noninvasive imaging of electrical potentials at the epicardium, known as ECGI, is increasingly applied in patients to assess normal and abnormal cardiac electrical activity. Body-surface potentials and epicardial potentials were recorded in normal anesthetized dogs. Computed tomography scanning provided a torso-heart geometry that was used to reconstruct epicardial potentials from body-surface potentials. Electrogram reconstructions attained a moderate accuracy compared with epicardial recordings (median correlation coefficient: 0.71), but with considerable variation (interquartile range: 0.36 to 0.86). This variation could be explained by a spatial mismatch (overall resolution was <20 mm) that was most apparent in regions with electrographic transition. More accurate derivation of activation times (Pearson R: 0.82), recovery times (R: 0.73), and the origin of paced beats (median error: 10 mm; interquartile range: 7 to 17 mm) was ac...Continue Reading

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Citations

May 13, 2018·Medical & Biological Engineering & Computing·Matthijs CluitmansRalf Peeters
Apr 28, 2018·Circulation. Arrhythmia and Electrophysiology·Laura R BearBruce H Smaill
Mar 22, 2019·JCI Insight·Andrew GraceGraydon Beatty
Apr 6, 2019·Circulation. Arrhythmia and Electrophysiology·Adam J GrahamPier D Lambiase
Jan 15, 2020·Circulation. Arrhythmia and Electrophysiology·Adam J GrahamPier D Lambiase
May 28, 2020·Medical & Biological Engineering & Computing·Hui Wang, Yong Wang
Aug 6, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Helder PereiraChristopher A Rinaldi
Feb 13, 2020·Journal of Cardiovascular Electrophysiology·Gurpreet S DhillonRoss J Hunter
Aug 1, 2019·Medical & Biological Engineering & Computing·Taha Erenler, Yesim Serinagaoglu Dogrusoz
Apr 27, 2019·Frontiers in Physiology·Erick Andres Perez AldayMichael A Colman
Feb 26, 2019·Frontiers in Physiology·Alexander KalininVitaly Kalinin
Dec 7, 2018·Medical & Biological Engineering & Computing·Önder Nazım OnakGerhard Wilhelm Weber
Nov 27, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Simone PezzutoAngelo Auricchio
Feb 16, 2021·Frontiers in Physiology·Miguel RodrigoSanjiv M Narayan
Aug 12, 2019·Cardiac Electrophysiology Clinics·Ghassen ChenitiMichel Haissaguerre
May 30, 2021·Computers in Biology and Medicine·Jake A BergquistRob S MacLeod
Jun 8, 2021·European Cardiology·Giulio La RosaDavid Filgueiras-Rama
Jul 28, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Katja E OdeningJordi Heijman
Nov 5, 2021·Proceedings of the National Academy of Sciences of the United States of America·Çağla ÖzsoyDaniel Razansky
Nov 9, 2021·Frontiers in Physiology·Jeanne G van der WaalRuben Coronel
Nov 18, 2021·Science Translational Medicine·Matthijs J M CluitmansPaul G A Volders

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