In vivo virtual intraoperative surgical photoacoustic microscopy

Applied Physics Letters
Seunghoon HanChulhong Kim

Abstract

We developed a virtual intraoperative surgical photoacoustic microscopy system by combining with a commercial surgical microscope and photoacoustic microscope (PAM). By sharing the common optical path in the microscope and PAM system, we could acquire the PAM and microscope images simultaneously. Moreover, by employing a beam projector to back-project 2D PAM images onto the microscope view plane as augmented reality, the conventional microscopic and 2D cross-sectional PAM images are concurrently mapped on the plane via an ocular lens of the microscope in real-time. Further, we guided needle insertion into phantom ex vivo and mice skins in vivo.

References

Jun 5, 2003·Nature Medicine·Donald M McDonald, Peter L Choyke
Feb 16, 2005·Archives of Ophthalmology·Gerd GeerlingReginald Birngruber
Mar 29, 2005·Optics Letters·Konstantin MaslovLihong V Wang
Mar 26, 2009·Plastic and Reconstructive Surgery·Aya MatsuiJohn V Frangioni
Jan 29, 2010·Klinische Monatsblätter für Augenheilkunde·G HüttmannR Birngruber
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Feb 2, 2011·Investigative Ophthalmology & Visual Science·Justis P EhlersCynthia A Toth

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Citations

Apr 30, 2015·Sensors·Jin Young KimChulhong Kim
Nov 29, 2016·Journal of Biomedical Optics·Paul Kumar Upputuri, Manojit Pramanik
Jan 4, 2019·Biomedical Engineering Letters·Paul Kumar Upputuri, Manojit Pramanik
Mar 18, 2021·Journal of Biophotonics·Yihao DuanKedi Xiong

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Methods Mentioned

BETA
surgical microscopy
fluorescence microscopy
imaging technique

Software Mentioned

VISPAM

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