In vivo wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography of human oral cavity with a forward-viewing probe

Biomedical Optics Express
Yeoreum YoonKi Hean Kim

Abstract

We report multimodal imaging of human oral cavity in vivo based on simultaneous wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography (PS-OCT) with a forward-viewing imaging probe. Wide-field reflectance/fluorescence imaging and PS-OCT were to provide both morphological and fluorescence information on the surface, and structural and birefringent information below the surface respectively. The forward-viewing probe was designed to access the oral cavity through the mouth with dimensions of approximately 10 mm in diameter and 180 mm in length. The probe had field of view (FOV) of approximately 5.5 mm in diameter, and adjustable depth of field (DOF) from 2 mm to 10 mm by controlling numerical aperture (NA) in the detection path. This adjustable DOF was to accommodate both requirements for image-based guiding with high DOF and high-resolution, high-sensitivity imaging with low DOF. This multimodal imaging system was characterized by using a tissue phantom and a mouse model in vivo, and was applied to human oral cavity. Information of surface morphology and vasculature, and under-surface layered structure and birefringence of the oral cavity tissues was obtained. These results showed fea...Continue Reading

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Citations

Jul 24, 2015·Biomedical Optics Express·Anthony M D LeePierre Lane
Oct 5, 2016·Biomedical Optics Express·Yeoreum YoonKi Hean Kim
Nov 4, 2016·Lasers in Medical Science·Priyanka SharmaPradeep Kumar Gupta
Jul 9, 2017·Journal of Biomedical Optics·Hsiang-Chieh LeeJames G Fujimoto
May 16, 2019·Biomedical Optics Express·Julia WaltherDavid D Sampson
Dec 17, 2016·Journal of Medical Imaging·Alessandro CosciCristina Kurachi
May 10, 2017·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Enrica GentileAlberta Lucchese

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