In169, a new class 1 integron that encoded bla(IMP-18) in a multidrug-resistant Pseudomonas aeruginosa isolate from Mexico

Archives of Medical Research
Guillermina Sanchez-MartinezJ Silva-Sanchez

Abstract

Carbapenem resistance in Pseudomonas aeruginosa may be due to the presence of metallo-beta-lactamases (MbetaL). The genes that encode these enzymes can be located in association with aminoglycoside-modifying enzymes on class 1 integrons. This study describes the bla(IMP-18) class 1 integron array (In169) from a carbapenem-resistant P. aeruginosa clinical isolate obtained at the Centro Medico Nacional La Raza (CMNR) in Mexico City and compares it to other bla(IMP)-type producers. Twenty six multiresistant P. aeruginosa clinical isolates were recovered between June and December 2004 and tested by MicroScan and CLSI agar dilution methods. The MbetaL production was screened by a disk approximation test and MbetaL Etest strips, whereas MbetaL genes and integrons were detected using PCR primers. DNA sequence analysis was carried out by BLAST, and epidemiological typing was performed by pulsed-field gel electrophoresis (PFGE). A Southern hybridization analysis was performed with a bla(IMP) specific DNA probe. Nine of 26 P. aeruginosa isolates were imipenem-resistant with unique PFGE patterns (no clonal relation), and only one strain (5106) was positive for MbetaL production, corresponding to the IMP-type. The class 1 integron encoding...Continue Reading

References

Jan 1, 1995·Antimicrobial Agents and Chemotherapy·C LévesqueP H Roy
Jun 9, 2005·Advanced Drug Delivery Reviews·Ayush Kumar, Herbert P Schweizer

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Citations

Aug 28, 2014·Critical Reviews in Microbiology·Jaime A LabarcaManuel Guzmán-Blanco
Dec 6, 2016·Expert Review of Anti-infective Therapy·Kevin Escandón-VargasMaría Virginia Villegas
Mar 24, 2016·Revista Do Instituto De Medicina Tropical De São Paulo·Bertinellys TeixeiraMarcos DE Donato
Jul 25, 2013·Expert Review of Anti-infective Therapy·Juan J MayaMaria V Villegas
Feb 1, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Jose Arturo Molina-MoraFernando García
Jun 3, 2021·Materials Today : Proceedings·Omar B AhmedFayez S Bahwerth

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