PMID: 9435253Jan 22, 1998Paper

Inability of keratinocytes lacking their specific transglutaminase to form cross-linked envelopes: absence of envelopes as a simple diagnostic test for lamellar ichthyosis

Proceedings of the National Academy of Sciences of the United States of America
S JeonH Green

Abstract

Epidermal keratinocytes, late in their terminal differentiation, form cross-linked envelopes resistant to ionic detergent and reducing agent. Because the cross-linking process is catalyzed by the keratinocyte transglutaminase, the absence of active transglutaminase should result in failure of the keratinocyte to form a cross-linked envelope. Three keratinocyte strains bearing mutations in the keratinocyte transglutaminase were examined: two contained no detectable transglutaminase mRNA and none contained active enzyme. All three were unable to form cross-linked envelopes, either spontaneously in stratified cultures or upon induction with Ca2+. Although stratum corneum of normal humans and scales from patients with different ichthyotic diseases contain cross-linked envelopes, those from patients with transglutaminase-negative lamellar ichthyosis do not. Therefore, the disease due to the absence of transglutaminase may be readily distinguished from other ichthyotic disease by a simple test for cross-linked envelopes.

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Citations

Sep 1, 2005·Archives of Dermatological Research·Robert H RicePeter M Elias
Dec 29, 1998·Journal of Dermatological Science·A Ishida-YamamotoH Iizuka
Oct 8, 1999·Journal of Dermatological Science·M Akiyama
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Jun 29, 2012·European Journal of Human Genetics : EJHG·Matthias SchmuthRobert Gruber
Nov 14, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·D Van GyselA P Oranje
Jul 10, 2002·Experimental Dermatology·Peter M EliasD Pharm
Apr 24, 2015·Biomolecules·Mark RinnerthalerKlaus Richter
Oct 19, 2000·The Journal of Cell Biology·P DjianH Green
Jan 20, 2012·Journal of Dermatological Science·Noboru NakagawaKiyofumi Yamanishi
Jul 8, 2000·The Journal of Investigative Dermatology·B A JessenR H Rice
Feb 20, 2002·The Journal of Investigative Dermatology·Michal JarnikAlasdair C Steven
Apr 23, 2004·The Journal of Investigative Dermatology·Matthias SchmuthPeter M Elias
Nov 25, 2003·The British Journal of Dermatology·R H RiceP M Elias
Jun 19, 2012·Biochimica Et Biophysica Acta·Angela SorrentinoLoredana Mariniello
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Feb 1, 2005·European Journal of Cell Biology·Patrick L J M Zeeuwen

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