Inability of naloxone to change brain morphine levels in tolerant mice

European Journal of Pharmacology
J DumD H Catlin

Abstract

The effect of naloxone on brain morphine concentrations was measured in naive and morphine-dependent mice using radioimmunoassay and gas-liquid chromatography. No displacement of morphine from the brain by naloxone could be observed in naive mice acutely injected with morphine or in pellet-implanted mice at increasing intervals after removal of the morphine pellets. The suggestion of a change in affinity of opiate receptors during the development of tolerance/dependence, which had been made on the basis of the displacement of morphine by naloxone found by other workers, is thus not supported by the present results.

References

Jan 1, 1976·Annals of the New York Academy of Sciences·E L Way, H H Loh
Jun 12, 1970·Science·S Spector, C W Parker

Citations

Aug 1, 1978·European Journal of Pharmacology·H N Bhargava
May 15, 1979·European Journal of Pharmacology·J DumA Herz
Oct 15, 1979·European Journal of Pharmacology·J DumA Herz

Related Concepts

Metazoa
Brain
Chromatography, Gas-Liquid
Drug Tolerance
Morphine Sulfate (2: 1), Pentahydrate
Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer
Radioimmunoassay
Mouse, Swiss

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