PMID: 11319310Apr 25, 2001Paper

Inability to noninvasively diagnose gastric intestinal metaplasia in Hispanics or reverse the lesion with Helicobacter pylori eradication

Journal of Clinical Gastroenterology
T G MoralesM B Fennerty

Abstract

Helicobacter pylori infection has been linked with the development of gastric adenocarcinoma and its precursor lesion, intestinal metaplasia (IM). The presence of gastric IM is not associated with symptoms, which makes identification of individuals with this lesion difficult. It is not clear whether eradication of H. pylori infection leads to reversal of gastric IM or the potential decrease in the risk of cancer in these patients. The purpose of this pilot study was to define the prevalence of gastric IM in a population at high risk for gastric cancer (Southwestern Hispanics), examine the ability of noninvasive testing to identify individuals with the lesion, and determine whether eradication of H. pylori infection reverses gastric IM in this population. Subjects from the Tucson metropolitan area were recruited, and baseline data, including the presence of upper gastrointestinal (UGI) symptoms, urinary sodium, and serum pepsinogen levels, were obtained. Upper endoscopy was performed and six gastric biopsies from specific anatomic sites were obtained, followed by methylene blue staining with targeted biopsies from blue-stained mucosa. Biopsies were evaluated for the presence of H. pylori infection and gastric IM. A subset of pat...Continue Reading

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Citations

Nov 7, 2001·Current Gastroenterology Reports·E J Kuipers, T A Grool
Aug 2, 2003·Gastroenterology·M Brian Fennerty
Jul 30, 2002·Alimentary Pharmacology & Therapeutics·W K Leung, J J Y Sung
Oct 23, 2002·Alimentary Pharmacology & Therapeutics·M HojoN Sato
Jan 26, 2010·Nutrition and Cancer·Marina Dias-NetoNuno Lunet
Nov 9, 2010·Nutrition and Cancer·Mariana PintalhaoNuno Lunet
Apr 19, 2003·Journal of Clinical Gastroenterology·Jaroslav ZivnyJeanMarie Houghton
Jun 10, 2011·American Journal of Clinical Oncology·Charles B SimoneJames M Metz
Feb 14, 2009·Journal of Gastroenterology and Hepatology·Rita A Busuttil, Alex Boussioutas
Nov 30, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Lucy VannellaBruno Annibale
Jan 19, 2007·Alimentary Pharmacology & Therapeutics·L FuccioF Bazzoli
Sep 1, 2005·The American Journal of Gastroenterology·Peter MalfertheinerUNKNOWN Lejondal H. pylori-Gastric Cancer Task Force
Feb 17, 2019·Digestive Diseases and Sciences·Judy A TrieuAndrew Y Wang

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