Inability to Process Negative Emotions in Cerebellar Damage: a Functional Transcranial Doppler Sonographic Study

The Cerebellum
Michela LupoMaria Leggio

Abstract

Recent studies have implicated the cerebellum as part of a circuitry that is necessary to modulate higher order and behaviorally relevant information in emotional domains. However, little is known about the relationship between the cerebellum and emotional processing. This study examined cerebellar function specifically in the processing of negative emotions. Transcranial Doppler ultrasonography was performed to detect selective changes in middle cerebral artery flow velocity during emotional stimulation in patients affected by focal or degenerative cerebellar lesions and in matched healthy subjects. Changes in flow velocity during non-emotional (motor and cognitive tasks) and emotional (relaxing and negative stimuli) conditions were recorded. In the present study, we found that during negative emotional task, the hemodynamic pattern of the cerebellar patients was significantly different to that of controls. Indeed, whereas relaxing stimuli did not elicit an increase in mean flow velocity in any group, negative stimuli increased the mean flow velocity in the right compared with left middle cerebral artery only in the control group. The patterns by which mean flow velocity increased during the motor and cognitive tasks were simi...Continue Reading

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Citations

Jan 12, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Wesley K LeffertsKevin S Heffernan
Aug 4, 2016·The Cerebellum·M AdamaszekJ Verhoeven
Feb 28, 2019·Addiction Biology·Chrysanthi BlithikiotiMercedes Balcells-Oliveró
Sep 16, 2019·The Cerebellum·Georgios P D ArgyropoulosJeremy D Schmahmann
Jun 9, 2020·Social Cognitive and Affective Neuroscience·Jordan E Pierce, Julie Péron
Sep 28, 2018·Frontiers in Neurology·Michela LupoMaria Leggio
Jul 3, 2017·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Paolo Alboni, Marco Alboni
Oct 28, 2019·Frontiers in Cellular Neuroscience·M Molinari, M Masciullo
Aug 19, 2020·Neuroscience and Biobehavioral Reviews·Ana P PinheiroSonja A Kotz
Jul 28, 2019·Frontiers in Neuroendocrinology·Josep Moreno-Rius
Apr 4, 2021·International Journal of Molecular Sciences·Michela LupoMaria Leggio

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