PMID: 2493380Feb 1, 1989Paper

Inaccurate calculation of drug output from nebulisers

European Journal of Pediatrics
C O'CallaghanA D Milner

Abstract

A multistage liquid impinger was used to collect the nebulised cloud from three separate nebulisers. The output of sodium cromoglycate collected was determined by a spectrophotometric assay. Estimating drug output purely from weight loss during nebulisation resulted in a considerable overestimate compared with direct assay of the drug output from the nebulised cloud. During nebulisation, weight loss from the nebuliser occurs in the form of particle formation and also by evaporation. By only weighing the nebuliser chamber before and after nebulisation, weight loss due to evaporation is not taken into account and this is the cause of the overestimation of drug output by this method.

References

May 1, 1987·Archives of Disease in Childhood·J N TsanakasA W Boon
Jan 1, 1986·British Journal of Diseases of the Chest·J W HadfieldJ R Bateman

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Citations

Jun 3, 1999·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·K E BendstrupJ I Jensen
Nov 7, 2000·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·A L CoatesL C Lands
Mar 3, 2011·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Allan L CoatesMartin Charron
Mar 21, 2013·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Wallace B WeeAllan L Coates
Aug 1, 1990·Archives of Disease in Childhood·M Silverman
Apr 17, 2013·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Allan L CoatesSharon D Dell
Mar 1, 1992·Journal of Medical Engineering & Technology·J H Dennis, D J Hendrick
Jul 1, 1994·Journal of Pharmaceutical Sciences·A Y Ip, R W Niven
May 1, 1996·Pediatric Pulmonology·J MallolC F Robertson
May 17, 2006·Pediatric Pulmonology·Sherri L KatzAllan L Coates
Jan 15, 1999·Pediatric Pulmonology·A L Coates, S L Ho
Apr 12, 2016·The Journal of Pharmacy and Pharmacology·Thiago C Carvalho, Jason T McConville

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