PMID: 2110633Mar 26, 1990Paper

Inactivation of a slow Ca2+ current in CA1 neurones of the adult rat hippocampal slice

Neuroscience Letters
A Nistri, E Cherubini

Abstract

CA1 neurones of the adult rat hippocampal slice preparation were voltage clamped at or near -40 mV membrane potential using a single electrode clamp method. Depolarizing voltage commands from a holding potential of -40 mV elicited voltage-dependent inward Ca2+ currents comprising a fast and a slow component. The latter one was investigated for its susceptibility to inactivation, which was maximally expressed at around 0 mV membrane potential. When extracellular Ca2+ was replaced by Ba2+, inward currents became much larger and were followed by long tail currents. Similar data were observed in neurones injected with the Ca2+ chelator BAPTA. It is suggested that inactivation of the slow Ca2+ current depends at least partly on the levels of intracellular free Ca2+ in hippocampal neurones.

References

Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D Tillotson
Jan 1, 1990·Epilepsy Research·E CherubiniA Nistri
Jan 1, 1989·Neuroscience·P G Kostyuk
Jan 1, 1984·Progress in Biophysics and Molecular Biology·R Eckert, J E Chad
Jan 1, 1981·Annual Review of Neuroscience·S Hagiwara, L Byerly

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