PMID: 7336466Dec 1, 1981Paper

Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo

Steroids
A M BrodieC H Robinson

Abstract

4-Hydroxy-4-androstene-3,17-dione (4-OHA) and 4-acetoxy-4-androstene-3,17-dione (4-AcA), in addition to being competitive inhibitors of aromatase, cause time-dependent, irreversible, loss of enzyme activity in both human placental and rat ovarian microsomes. In vivo, treatment of rats with 4-OHA also causes loss of ovarian aromatase activity. To test whether this loss of activity could have in vivo significance, rats with hormone-dependent, mammary tumors were treated with 4-OHA on alternate weeks. Tumor regression continued to occur during the weeks without treatment. These findings suggest that inactivation of aromatase is important in the mechanism of action of the compounds in vivo.

References

Oct 1, 1976·Journal of Steroid Biochemistry·A M BrodieH J Brodie
Aug 1, 1981·Journal of Steroid Biochemistry·A M BrodieK I Williams

❮ Previous
Next ❯

Citations

Jan 1, 1994·Breast Cancer Research and Treatment·A M Brodie, R J Santen
Jan 1, 1994·Breast Cancer Research and Treatment·R W Brueggemeier
Jan 1, 1994·Breast Cancer Research and Treatment·G Cocconi
Jan 1, 1994·Breast Cancer Research and Treatment·M Dowsett, R C Coombes
Aug 13, 2002·Pathology Oncology Research : POR·Magdolna Dank
Nov 2, 2007·Medical Oncology·Udayan Dutta, Kartikeya Pant
Jan 1, 1986·Journal of Steroid Biochemistry·A M BrodieR C Coombes
Feb 1, 1986·Journal of Steroid Biochemistry·A B FosterI B Parr
Nov 1, 1986·Journal of Steroid Biochemistry·A M BrodieR C Coombes
Nov 1, 1986·Journal of Steroid Biochemistry·D HendersonM F el Etreby
Jan 1, 1987·Journal of Steroid Biochemistry·A M BrodieM Dowsett
Jan 1, 1987·Journal of Steroid Biochemistry·D Henderson
Jan 1, 1988·Journal of Steroid Biochemistry·D GiudiciE di Salle
Jan 1, 1989·Journal of Steroid Biochemistry·E di SalleT Zaccheo
May 1, 1989·Journal of Steroid Biochemistry·G H Deckers, A H Schuurs
Jan 1, 1990·Journal of Steroid Biochemistry·Y J Abul-Hajj
Jul 1, 1987·Steroids·G D BerkovitzM Fujimoto
Mar 1, 1985·Steroids·J P BurkhartJ O Johnston
Oct 1, 1987·Steroids·N J MacLuskyF Naftolin
Sep 1, 1990·Steroids·J O JohnstonJ C Melby
Dec 1, 1993·Pharmacology & Therapeutics·A M Brodie
Apr 28, 1995·Molecular and Cellular Endocrinology·F JakobJ Köhrle
Dec 1, 1995·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·S MoslemiJ L Gaillard
Jun 1, 1989·Cancer Treatment Reviews·W R Miller
Jan 1, 1991·Domestic Animal Endocrinology·L A O'NeillR P Wettemann
Dec 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·A M BrodieR D Koos
Nov 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·A M BrodieR C Coombes
Nov 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·R W BrueggemeierN E Katlic
Nov 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·M Dowsett
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·A Brodie
Sep 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·E di SalleR C Coombes
Sep 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·M DowsettR C Coombes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.