Inactivation of basolateral amygdala prevents chronic immobilization stress-induced memory impairment and associated changes in corticosterone levels

Neurobiology of Learning and Memory
Sunil Jamuna TripathiB S Shankaranarayana Rao

Abstract

Chronic stress causes detrimental effects on various forms of learning and memory. The basolateral amygdala (BLA) not only plays a crucial role in mediating certain forms of memory, but also in the modulation of the effects of stress. Chronic immobilization stress (CIS) results in hypertrophy of the BLA, which is believed to be one of the underlying causes for stress' effects on learning. Thus, it is plausible that preventing the effects of CIS on amygdala would preclude its deleterious cognitive effects. Accordingly, in the first part, we evaluated the effect of excitotoxic lesion of the BLA on chronic stress-induced hippocampal-dependent spatial learning using a partially baited radial arm maze task. The BLA was ablated bilaterally using ibotenic acid prior to CIS. Chronically stressed rats showed impairment in spatial learning with decreased percentage correct choice and increased reference memory errors. Excitotoxic lesion of the BLA prevented the impairment in spatial learning and reference memory. In the retention test, lesion of the BLA was able to rescue the chronic stress-induced impairment. Interestingly, stress-induced enhanced plasma corticosterone levels were partially prevented by the lesion of BLA. These results ...Continue Reading

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Citations

Apr 29, 2018·Molecular Neurobiology·Sunil Jamuna TripathiB S Shankaranarayana Rao
Nov 30, 2018·Journal of Psychopharmacology·Bettadapura N SrikumarReeba K Vikramadithyan
Jun 24, 2020·Psychopharmacology·Suwarna ChakrabortyB S Shankaranarayana Rao
Mar 23, 2018·Journal of Integrative Neuroscience·V PriyaB S Shankaranarayana Rao
Nov 13, 2021·The European Journal of Neuroscience·Prabahan ChakrabortyFreddy Jeanneteau

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