PMID: 7521855Aug 1, 1994Paper

Inactivation of bleomycin by an N-acetyltransferase in the bleomycin-producing strain Streptomyces verticillus

FEMS Microbiology Letters
M SugiyamaJ E Davies

Abstract

Bleomycin-producing Streptomyces verticillus ATCC15003 possesses a bleomycin acetyltransferase which inactivates the drug in the presence of acetyl coenzyme A. The site of acylation in enzymically prepared acetylbleomycin A2 was determined by nuclear magnetic resonance analysis; the primary amino group of the beta-aminoalanine moiety of bleomycin was acetylated Acetylbleomycin A2 had no detectable antibacterial activity and did not induce in vitro DNA degradation.

References

Mar 28, 1988·FEBS Letters·A GatignolG Tiraby
Jul 16, 1981·Biochemical and Biophysical Research Communications·S AkiyamaM Kuwano

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Citations

Oct 20, 2005·Journal of Bioscience and Bioengineering·Masanori Sugiyama, Takanori Kumagai
Nov 6, 2009·The Journal of Biological Chemistry·Kosuke OdaMasanori Sugiyama
Oct 12, 2010·Chemistry : a European Journal·Jason C Kwan, Hendrik Luesch
Feb 19, 2013·Journal of Basic Microbiology·Ajithkumar VasanthakumarRanjan Prasad
Oct 12, 2013·Chembiochem : a European Journal of Chemical Biology·Xiaoyu TangBertolt Gust
Jul 24, 2004·Chemistry & Biology·Michele GunsiorCraig A Townsend
Mar 28, 2009·Biochemical and Biophysical Research Communications·Satoshi SuzukiMasanori Sugiyama
Feb 24, 2011·Microbial Biotechnology·Carlos OlanoJosé A Salas
Jan 11, 2017·Antimicrobial Agents and Chemotherapy·Laurent DortetThierry Naas
Feb 11, 2005·Chemical Reviews·Ute GalmBen Shen
Dec 1, 1995·Applied and Environmental Microbiology·P C Gilcrease, V G Murphy

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