PMID: 7018895Aug 1, 1980Paper

Inactivation of bronchial mucous proteinase inhibitor by cigarette smoke and phagocyte-derived oxidants

Experimental Lung Research
H Carp, A Janoff

Abstract

Freshly prepared aqueous solutions of cigarette smoke suppressed the elastase inhibitory capacity (EIC) of the acid-stable proteinase inhibitor present in bronchial mucus (BMPi) and human seminal plasma (HUSI-I). Thin-layer gel-immunofiltration analysis of mixtures of smoke-treated BMPi and human leukocyte elastase showed decreased elastase: BMPi complexes, increased uncomplexed BMPi and increased free elastase. Phenolic antioxidants prevented the suppression of the EIC of BMPi or HUSI-I by cigarette smoke. In addition, treatment of BMPi or HUSI-I with chemical oxidants caused a similar suppression of EIC. Furthermore, treatment of BMPi or HUSI-I with the phagocyte-derived oxidizing system, myeloperoxidase + H2O2 + Cl-, suppressed EIC. Finally, the functional activity of BMPi was significantly reduced in tracheal aspirates of human smokers compared to that of nonsmokers. These results support the hypothesis that local inactivation of BMPi in the conducting airways of the lung by inhaled cigarette smoke or by phagocyte-derived oxidants may play a role in the pathogenesis of obstructive lung disease in smokers.

References

Mar 23, 1978·The New England Journal of Medicine·B M Babior
Nov 1, 1978·European Journal of Immunology·A SolomonK Havemann
May 28, 1979·Biochemical and Biophysical Research Communications·N R MathesonJ Travis
Oct 1, 1979·The Journal of Clinical Investigation·R A Clark, S J Klebanoff
May 1, 1978·The Journal of Pathology·J A Hayes, T G Christensen
Mar 1, 1977·The Journal of Clinical Investigation·T G ChristensenJ A Hayes
May 1, 1977·Hoppe-Seyler's Zeitschrift für physiologische Chemie·K OhlssonU Akesson
Oct 7, 1975·Biochemistry·Y ShechterA Patchornik
Jan 1, 1972·Annual Review of Medicine·A Janoff
Sep 1, 1974·Hoppe-Seyler's Zeitschrift für physiologische Chemie·W Schmidt, K Havemann
Apr 1, 1968·Chemical Reviews·R L Stedman
Sep 1, 1965·Journal of Clinical Pathology·G H Grant, P H Everall
Feb 6, 1954·Lancet·L M REID

❮ Previous
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Citations

Jan 1, 1996·Free Radical Biology & Medicine·I Rahman, W MacNee
Oct 20, 2010·The Journal of Biological Chemistry·Daniela N PetruscaIrina Petrache
May 9, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sadaf SohrabIrina Petrache
Jan 1, 1991·Annals of the New York Academy of Sciences·J A KrampsJ H Dijkman
Aug 17, 2010·American Journal of Respiratory and Critical Care Medicine·Kelly S SchweitzerIrina Petrache
Sep 1, 2012·American Journal of Respiratory Cell and Molecular Biology·Linden A GreenMatthias Clauss
Nov 4, 2005·Proceedings of the American Thoracic Society·Caroline A Owen
Jul 1, 2005·Treatments in Respiratory Medicine·Irfan Rahman
May 28, 1993·Annals of the New York Academy of Sciences·C K Chow
May 28, 1993·Annals of the New York Academy of Sciences·W A Pryor, K Stone
Apr 7, 2009·Diabetes Research and Clinical Practice·Minoo YaghmaeiSaeid Ghavami
May 1, 1992·Respiratory Medicine·T D Tetley
Oct 16, 1999·The Journal of Laboratory and Clinical Medicine·C A Owen, E J Campbell
Jun 24, 1988·The American Journal of Medicine·J Travis
Mar 15, 1989·Biochemical and Biophysical Research Communications·R T DeanH P Schnebli
Aug 1, 1997·The Tohoku Journal of Experimental Medicine·Y AndohK Shirato
Jun 28, 2011·The American Journal of Pathology·Robert G PressonIrina Petrache
Oct 24, 2007·Current Topics in Developmental Biology·Derek B Oien, Jackob Moskovitz
Jun 1, 1984·Circulation Research·K L Brigham, B Meyrick
Apr 27, 2013·Nature Reviews. Immunology·Carl Nathan, Amy Cunningham-Bussel
Dec 10, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Linden A GreenMatthias Clauss
Nov 17, 1994·Annals of the New York Academy of Sciences·M A SmithG Perry
Aug 30, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kelly S SchweitzerIrina Petrache
Mar 1, 1986·Biological Chemistry Hoppe-Seyler·S F SmithT D Tetley
Dec 22, 1999·The American Journal of Physiology·I Rahman, W MacNee
Apr 1, 1995·Trends in Neurosciences·M A SmithG Perry

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