Inactivation of cephalothin and cephaloridine by Staphylococcus aureus.

Journal of Bacteriology
E J BennerW M Kirby

Abstract

Benner, Ernest J. (University of Washington School of Medicine, Seattle), John V. Bennett, Jean L. Brodie, and William M. M. Kirby. Inactivation of cephalothin and cephaloridine by Staphylococcus aureus. J. Bacteriol. 90:1599-1604. 1965.-Marked differences were observed in the susceptibility of penicillinase-producing staphylococci to cephalothin and cephaloridine. All of 100 strains of penicillin G-resistant Staphylococcus aureus, with the use of a large inoculum, were found to be susceptible to 2 mug/ml of cephalothin, whereas only 50% were susceptible to this concentration of cephaloridine, and 15% required 15 mug/ml or more for inhibition. In contrast, penicillin G-sensitive strains were more susceptible to cephaloridine and did not show the marked inoculum effect observed with the cephaloridine-resistant strains. These differences were due to a much greater destruction of cephaloridine than of cephalothin by staphylococcal penicillinase. Cephaloridine-resistant staphyloccoci were stronger penicillinase producers than were susceptible strains, and the resistant strains were found to inactivate cephaloridine by hydrolysis of the beta-lactam ring. In population studies, cephaloridine-resistant cells differed from methicillin-...Continue Reading

References

Jul 27, 1963·British Medical Journal·G A AYLIFFE, M BARBER
Jul 27, 1963·British Medical Journal·R KNOX, J T SMITH
Apr 1, 1964·Journal of Bacteriology·R SUTHERLAND, G N ROLINSON
Nov 14, 1964·British Medical Journal·P W MUGGLETONW K STEVENS
Dec 19, 1964·Lancet·G T STEWART, R J HOLT
Jan 1, 1964·Acta Pathologica Et Microbiologica Scandinavica·K R ERIKSEN, I ERICHSEN
Apr 1, 1965·Journal of Bacteriology·C F GRAVENKEMPERW M KIRBY

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Citations

Aug 1, 1973·Journal of Clinical Pathology·A D Russell, J R Furr
Jun 1, 1969·The Journal of Pharmacy and Pharmacology·J T SmithR Knox
Sep 27, 1967·Annals of the New York Academy of Sciences·J C SherrisG A Lighthart
Dec 21, 1974·The Medical Journal of Australia·S M Bell
Feb 1, 1992·Antimicrobial Agents and Chemotherapy·D J ZygmuntD S Kernodle
Apr 1, 1973·Antimicrobial Agents and Chemotherapy·L B RellerM Turck
Jun 1, 1976·Antimicrobial Agents and Chemotherapy·I W FongW M Kirby
Mar 1, 1981·The Journal of Hospital Infection·D C Shanson

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