PMID: 9438984Jan 24, 1998Paper

Inactivation of Cu,Zn-superoxide dismutase by intermediates of Maillard reaction and glycolytic pathway and some sugars

Bioscience, Biotechnology, and Biochemistry
Hiroyuki UkedaMasayoshi Sawamura

Abstract

Human Cu,Zn-superoxide dismutase (SOD) was incubated with various intermediates of the Maillard reaction and glycolytic pathway (arabinose, glyoxal, glycolaldehyde, glyceraldehyde, glyceraldehyde 3-phosphate, and dihydroxyacetone) and some reducing sugars (sorbose, xylose, and ribose). The change of the activity and the molecular weight were measured and compared with that of SOD incubated with glucose or fructose. Sorbose, xylose, and ribose decreased the activity with a rate comparable to fructose. Site-specific and random fragmentation were observed upon the incubation with them. Arabinose showed a similar inactivation rate as glucose. The intermediates other than arabinose had a high inactivation rate. Especially, glyceraldehyde, glycolaldehyde, and glyoxal most strongly lowered the activity in a concentration-dependent manner and a significant inactivation was recognized even at 1 mM level. SDS-PAGE band patterns indicated that the inactivation by those carbonyl compounds occurred by both crosslinking and site-specific fragmentation of SOD.

Citations

Jul 16, 2010·Cardiovascular Toxicology·Rodrigo LorenziJosé Cláudio Fonseca Moreira
May 19, 2012·Nature Chemical Biology·Arren Bar-EvenRon Milo
Jan 19, 2006·Critical Reviews in Toxicology·Peter J O'BrienNandita Shangari
Jul 8, 2010·Diabetes Research and Clinical Practice·Rodrigo LorenziJosé Cláudio Fonseca Moreira
Sep 11, 2004·Biochemical and Biophysical Research Communications·Hiroyoshi IwataMasayoshi Sawamura
Mar 21, 2006·Free Radical Biology & Medicine·Khazna S Al-EneziLudmil T Benov
Mar 8, 2013·Dermato-endocrinology·Paraskevi Gkogkolou, Markus Böhm
Sep 30, 2016·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Ana Flávia Marçal PessoaMarinilce Fagundes Santos
Jul 14, 2017·Canadian Journal of Physiology and Pharmacology·Olivier Kamtchueng SimoAbdelouahed Khalil
Mar 8, 2011·International Journal of Toxicology·Rodrigo LorenziJosé Cláudio Fonseca Moreira
Jul 17, 2001·The British Journal of Dermatology·C JeanmaireG Pauly
Oct 29, 2002·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Hiroyuki UkedaMasayoshi Sawamura
Jul 31, 2019·Reproduction in Domestic Animals = Zuchthygiene·Jacek WawrzykowskiMarta Kankofer
Apr 8, 2004·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Hiroyuki UkedaMasayoshi Sawamura
Jul 20, 2016·Reviews in Endocrine & Metabolic Disorders·E MakrantonakiC C Zouboulis

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