Inactivation of exogenous surfactant in experimental respiratory failure induced by hyperoxia

Acta Anaesthesiologica Scandinavica
J J EnnemaT Curstedt

Abstract

Adult guinea pigs were exposed to 100% oxygen until, after 54-85 h, they developed severe respiratory insufficiency. One subgroup of animals was ventilated artificially with 100% oxygen for an additional 60-960 min. When the PaO2 was less than 15 kPa or the PaCO2 greater than 20 kPa, 1 ml of porcine surfactant (phospholipid concentration 80 mg.ml-1) was instilled via the trachea. These animals were ventilated for one more hour and then sacrificed. Surfactant instillation did not improve the blood gases, nor the pulmonary pressure-volume characteristics. All hyperoxia-exposed guinea pigs showed prominent histologic lung lesions, including intraalveolar edema and desquamation of airway epithelium. Compared to normal guinea pigs the volume density of intraalveolar "gas" was decreased and that of intraalveolar fluid increased. The alveolar expansion pattern in histologic sections was not improved in the surfactant-treated animals, compared to hyperoxia-exposed guinea pigs studied immediately after death. In hyperoxia-exposed animals, about 1.5 ml of edema fluid was sampled from the airways. Evaluated with pulsating bubble, our surfactant preparation had a minimum surface tension (gamma min) close to zero. However, the gamma min val...Continue Reading

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Citations

Apr 1, 1990·Acta Anaesthesiologica Scandinavica·T KobayashiS Murakami
Jan 1, 1991·Acta Anaesthesiologica Scandinavica. Supplementum·B Robertson
Jan 1, 1994·Acta Anaesthesiologica Scandinavica·W Z LiT Kobayashi
Oct 1, 1996·Acta Anaesthesiologica Scandinavica·G W SongW X Huang
Aug 12, 1998·American Journal of Respiratory and Critical Care Medicine·G F ZhuB Robertson
Feb 15, 2000·American Journal of Respiratory and Critical Care Medicine·Z H ZhouL W Zhu
Jan 1, 1995·European Journal of Pediatrics·M Amato
Nov 1, 1996·Thorax·M J KreschR S Thrall

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