PMID: 9450641Feb 5, 1998Paper

Inactivation of glyceraldehyde-3-phosphate dehydrogenase of human malignant cells by methylglyoxal

Molecular and Cellular Biochemistry
M RayS Ray

Abstract

The effect of methylglyoxal on the activity of glyceraldehyde-3-phosphate dehydrogenase (GA3PD) of several normal human tissues and benign and malignant tumors has been tested. Methylglyoxal inactivated GA3PD of all the malignant cells (47 samples) and the degree of inactivation was in the range of 25-90%, but it had no inhibitory effect on this enzyme from several normal cells (24 samples) and benign tumors (13 samples). When the effect of methylglyoxal on other two dehydrogenases namely glucose 6-phosphate dehydrogenase (G6PD) and L-lactic dehydrogenase (LDH) of similar cells was tested as controls it has been observed that methylglyoxal has some inactivating effect on G6PD of all the normal, benign and malignant samples tested, whereas, LDH remained completely unaffected. These studies indicate that the inactivating effect of methylglyoxal on GA3PD specifically of the malignant cells may be a common feature of all the malignant cells, and this phenomenon can be used as a simple and rapid device for the detection of malignancy.

Citations

Nov 18, 2009·Biochemistry. Biokhimii︠a︡·D TalukdarS Ray
Apr 26, 2011·Molecular Biotechnology·Ashok D ChougaleMahesh J Kulkarni
Feb 6, 2014·Physical Chemistry Chemical Physics : PCCP·Srabanti GhoshSomobrata Acharya
Sep 25, 2017·Biochemistry. Biokhimii︠a︡·V I MuronetzE V Schmalhausen
Sep 15, 2009·Biochemistry. Biokhimii︠a︡·S PatraM Ray
Sep 12, 2012·Oncotarget·Shanmugasundaram Ganapathy-KanniappanJean-Francois Geschwind
Dec 26, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Babett BartlingAndreas Simm
Jan 16, 2003·Biochimica Et Biophysica Acta·Paul J BeisswengerBenjamin S Szwergold
Jul 12, 2008·International Immunopharmacology·Nivedita BhattacharyyaManju Ray

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