Inactivation of infectious bursal disease virus by binary ethylenimine and formalin

Journal of Zhejiang University. Science. B
M HabibHamid Irshad

Abstract

In this experiment conducted to study the inactivation dynamics of infectious bursal disease virus (IBDV) by binary ethylenimine (BEI) in comparison with formalin, IBDV was isolated from the bursa of infected chickens and its confirmation was done by agar gel precipitation test. Viral suspensions were subjected to inactivation with BEI and formalin for pre-set time intervals. BEI was employed at concentrations of 0.001 and 0.002 mol/L while formalin was used at 0.1% and 0.2%. Sampling was done at 6, 12, 24, 36 and 48 h of incubation and samples were tested for their inactivation status in 9-day-old embryonated eggs and 3-week-old broiler chickens. IBDV was completely inactivated by 0.001 and 0.002 mol/L BEI after 36 h of incubation at 37 degrees C, whereas formalin at 0.1% and 0.2% concentrations inactivated IBDV in 24 h.

References

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Citations

Jul 18, 2006·Journal of Zhejiang University. Science. B·Mudasser HabibNing Chen
Mar 10, 2009·Fish & Shellfish Immunology·Fei ZhuZi-Rong Xu
Jun 6, 2017·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Rai Shafqat Ali KhanMaliha Sarfraz

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