Abstract
Recently we have heard warnings of an outbreak of a highly pathogenic avian influenza virus (H5N1). Although, to prevent such infections we must prepare anti-viral drugs and type-specific vaccines against influenza, we need various simple and effective protection methods, such as the use of face masks for public health. Also, in any consideration of bacterial infections, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococci (VRE), and multidrug-resistant Pseudomonas aeruginosa (MDRP) also pose serious concerns which must be addressed. I examined the antiviral activity of gentian violet (GV) and GV-dyed cloth against the influenza A (H1N1) virus. Time-kill studies were carried out, and the virus titer was determined based on the 50% tissue culture infective dose (TCID50). The minimum inhibitory concentrations (MICs) of GV against bacteria were also determined, and the killing activities of the GV-dyed cloth were judged from viable cell counts. GV immediately killed the influenza A virus and this was confirmed by electron microscopy. Moreover, cloth dyed with a combination of GV and copper showed not only excellent antiviral activity but also prominent bactericidal activities.
References
Jan 1, 1990·Drug Metabolism Reviews·R Docampo, S N Moreno
May 10, 2003·Lancet·W H SetoUNKNOWN Advisors of Expert SARS group of Hospital Authority
Jul 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·H ChenK Yu
Sep 1, 2004·Lancet·Maki KisoYoshihiro Kawaoka
Sep 4, 2004·Science·Thijs KuikenAlbert Osterhaus
Dec 4, 2004·Nature Medicine·Peter Palese
Dec 25, 2004·Science·Klaus Stöhr, Marja Esveld
Jan 15, 2005·Nature·Peter Aldhous
Jan 26, 2005·The New England Journal of Medicine·Kumnuan UngchusakSupamit Chunsutthiwat
Feb 4, 2005·The New England Journal of Medicine·Sophia V KazakovaDaniel B Jernigan
Apr 9, 2005·The New England Journal of Medicine·Scott K FridkinUNKNOWN Active Bacterial Core Surveillance Program of the Emerging Infections Program Network
Apr 9, 2005·The New England Journal of Medicine·Henry F Chambers
May 6, 2005·The New England Journal of Medicine·Michael T Osterholm
May 27, 2005·Nature·Erika Check
May 27, 2005·Nature·Alison Abbott
Jun 22, 2005·International Journal of Medical Sciences·James E Hollenbeck
Jul 8, 2005·Science·J LiuG F Gao
Jul 12, 2005·Nature·H ChenY Guan
Sep 30, 2005·The New England Journal of Medicine·John H BeigelUNKNOWN Writing Committee of the World Health Organization (WHO) Consultation on Human Influenza A/H5
Oct 7, 2005·Nature·Jeffery K TaubenbergerThomas G Fanning
Oct 8, 2005·Science·Terrence M TumpeyAdolfo García-Sastre
Oct 18, 2005·Nature·Q Mai LeYoshihiro Kawaoka
Citations
Nov 6, 2009·Virology Journal·Mohamad AljofanBruce A Mungall
Aug 15, 2015·Clinical and Experimental Vaccine Research·Ho Seong Seo
Oct 29, 2019·Current Molecular Pharmacology·Shreya BhattacharyaSujay Ray
Sep 18, 2008·ANZ Journal of Surgery·John RooneySydney Bell
Aug 13, 2011·Mycopathologia·Shigemi KondoTakashi Miida
Jul 3, 2021·Medicines·Hiroshi SakagamiSatoshi Yokose