Inactivation of influenza A virus via exposure to silver nanoparticle-decorated silica hybrid composites

Environmental Science and Pollution Research International
SungJun ParkGwangPyo Ko

Abstract

Influenza A virus (IFV-A) is one of the main cause of seasonal flu and can infect various of host species via the reassortment of segmented RNA genomes. Silver nanoparticles (AgNPs) have been known as excellent antiviral agent against IFV. However, the use of free AgNPs has several major drawbacks, including the inherent aggregation among AgNPs and unwanted cytotoxic or genotoxic damages for human body via inhalation or ingestion. In this study, we assessed the efficacy of our novel ~ 30-nm-diameter AgNP-decorated silica hybrid composite (Ag30-SiO2; ~ 400 nm in diameter) for IFV-A inactivation. Ag30-SiO2 particles can inhibit IFV-A effectively in a clear dose-dependent manner. However, when real-time RT-PCR assay was used, merely 0.5-log10 reduction of IFV-A was observed at both 5 and 20 °C. Moreover, even after 1 h of exposure to Ag30-SiO2 particles, more than 80% of hemagglutinin (HA) damage and 20% of neuraminidase (NA) activities had occurred, and the infection of Madin-Darby Canine Kidney (MDCK) cells by IFV-A was reduced. The results suggested that the major antiviral mechanism of Ag30-SiO2 particles is the interaction with viral components located at the membrane. Therefore, Ag30-SiO2 particles can cause nonspecific dama...Continue Reading

References

Mar 8, 2000·Bioscience, Biotechnology, and Biochemistry·K HayashiY Suzuki
Jan 31, 2007·Nature Reviews. Genetics·Martha I Nelson, Edward C Holmes
Feb 9, 2008·Emerging Infectious Diseases·Yu YamamotoMasaji Mase
Feb 25, 2009·ACS Nano·P V AshaRaniSuresh Valiyaveettil
Jun 16, 2009·Nature·Gabriele NeumannYoshihiro Kawaoka
Nov 10, 2009·Veterinary Immunology and Immunopathology·Timm C Harder, Thomas W Vahlenkamp
Nov 17, 2009·Zoonoses and Public Health·I N KandunT Wandra
Dec 30, 2009·Applied and Environmental Microbiology·Mi Young LimGwangPyo Ko
Feb 11, 2010·Journal of Nanobiotechnology·Humberto H LaraCristina Rodriguez-Padilla
Aug 5, 2011·Journal of Nanobiotechnology·Humberto H LaraDinesh K Singh
Jun 23, 2012·Science·Sander HerfstRon A M Fouchier
Feb 21, 2013·Nanoscale Research Letters·Yasutaka MoriMasayuki Ishihara
May 21, 2013·Current Protocols in Microbiology·Amanda L BalishAlexander I Klimov
Feb 4, 2014·Applied and Environmental Microbiology·SungJun ParkGwangPyo Ko
Jul 29, 2017·The Science of the Total Environment·SungJun ParkGwangPyo Ko
Feb 15, 2018·International Journal of Nanomedicine·Shahid Ullah KhanShah Fahad
Jun 7, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hye Hun ParkKyoungja Woo
Oct 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Young-Seon KoKyoungja Woo

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Citations

Sep 7, 2020·Journal of Nanobiotechnology·Estefânia V R CamposLeonardo Fernandes Fraceto
Feb 9, 2021·Frontiers in Microbiology·Idessania Nazareth CostaEloisa Amália Vieira Ferro
Feb 28, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Fernanda PilaquingaMaría de Las Nieves Piña
Sep 5, 2021·Environmental Science and Pollution Research International·Krishna Priyadarshini DasBhabani K Satapathy

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