Inactivation of Kupffer cells by gadolinium administration prevents lipopolysaccharide-induced decrease in liver insulin-like growth factor-I and IGF-binding protein-3 gene expression

The Journal of Endocrinology
M GranadoA López-Calderón

Abstract

Gram-negative bacterial infection or treatment of animals with bacterial lipopolysaccharide (LPS) induces a catabolic state with proteolysis, liver injury and an inhibition of the insulin-like growth factor-I (IGF-I) system. The purpose of this work was to elucidate the role of Kupffer cells in LPS-induced inhibition of the IGF-I/IGF-binding protein-3 (IGFBP-3) system. Adult male Wistar rats were either pretreated with the Kupffer cell inhibitor gadolinium chloride (10 mg/kg, i.v., 24 h prior to LPS exposure) or saline vehicle. Rats received two i.p. injections of 1 mg/kg LPS (at 17:30 and 08:30 h the following day) and were killed 4 h after the second injection. LPS administration induced a significant decrease in body weight and in serum concentrations of IGF-I and IGFBP-3 (P < 0.01), as well as in their gene expression in the liver. LPS-injected rats had increased serum concentrations of ACTH, corticosterone (P < 0.05), tumour necrosis factor-alpha (TNF-alpha) and nitrites (P < 0.01). Pretreatment of the animals with gadolinium chloride blocked the inhibitory effect of LPS on body weight, and on serum concentrations of IGF-I, IGFBP-3 and nitrites, as well as growth hormone receptor (GHR), IGF-I and IGFBP-3 gene expression in...Continue Reading

Citations

Jul 20, 2012·International Journal of Hepatology·Takeshi NowatariNobuhiro Ohkohchi
Sep 12, 2009·Journal of Child Neurology·Xiaoyang WangCarina Mallard
Oct 9, 2014·Mediators of Inflammation·Ana Isabel MartínAsunción López-Calderón
Mar 4, 2008·World Journal of Surgery·Soichiro MurataNobuhiro Ohkohchi
Jan 28, 2016·Analytical Chemistry·Joseph R MazzulliHarry Ischiropoulos
Dec 1, 2008·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Mónica CastellanosFrancisco Vargas-Albores
Sep 21, 2007·Advanced Drug Delivery Reviews·El-Sayed KhafagyKozo Takayama
Mar 14, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Jun-Hua FanNaohisa Ishikawa
Jul 4, 2018·American Journal of Physiology. Endocrinology and Metabolism·Ana Isabel MartínAsunción López-Calderón
May 13, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Justin D EllettKenneth D Chavin
Nov 19, 2010·Revista do Colégio Brasileiro de Cirurgiões·Diego da Fonseca MossmannAlessandro Bersch Osvaldt
Nov 8, 2007·American Journal of Physiology. Endocrinology and Metabolism·Miriam GranadoM Angeles Villanúa

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