Mar 16, 2016

Inactivation of Lytic Transglycosylases Increases Susceptibility to Aminoglycosides and Macrolides by Altering the Outer Membrane Permeability of Stenotrophomonas maltophilia

Antimicrobial Agents and Chemotherapy
Chao-Jung WuTsuey-Ching Yang

Abstract

Stenotrophomonas maltophilia harbors six lytic transglycosylases (LTs): mltA, mltB1, mltB2, mltD1, mltD2, and slt LT deletion increased susceptibility of S. maltophilia to aminoglycosides (AGs) and macrolides, and the underlying mechanisms were investigated. The expression of AG-modifying enzymes and efflux pumps was evaluated by quantitative reverse transcription-PCR (qRT-PCR). Susceptibility to 1-N-phenylnaphthylamine, vancomycin, SDS, and bile salts was measured to assess outer membrane permeability. In conclusion, increased outer membrane permeability contributes to LT deletion-mediated increase in aminoglycoside and macrolide susceptibility.

  • References17
  • Citations6

Mentioned in this Paper

Vancomycin
AB-Vancomycin
Aminoglycoside [EPC]
Bile Acid Measurement
Bacterial Proteins
Outer Membrane
Enzymes, antithrombotic
Aminoglycosides
Bacteriocidal Agents
Antibiotic throat preparations

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