Inactivation of macrolides by producers and pathogens

Current Drug Targets. Infectious Disorders
Mayumi Matsuoka, Tsuguo Sasaki

Abstract

Inactivation, one of the mechanisms of resistance to macrolide, lincosamide and streptogramin (MLS) antibiotics, appears to be fairly rare in clinical isolates in comparison with target site modification or efflux. However, inactivation is one of the major mechanisms through which macrolide-producing organisms avoid self-damage during antibiotic biosynthesis. The inactivation mechanisms for MLS antibiotics in pathogens are mainly hydrolysis, phosphorylation, glycosylation, reduction, deacylation, nucleotidylation, and acetylation. The ere (erythromycin resistance esterase) and mph (macrolide phosphotransferase) genes were originally found in Escherichia coli. Subsequently, Wondrack et al. (Wondrack, L.; Massa, M.; Yang, B.V.; Sutcliffe, J. Antimicrob. Agents Chemother., 1996, 40, 992) reported ere-like activity in Staphylococcus aureus. In addition, a variant of erythromycin esterase was found in Pseudomonas sp. from aquaculture sediment by Kim et al. (Kim, Y.H.; Cha, C.J.; Cerniglia, C.E. FEMS Microbiol. Lett., 2002, 210, 239). Although the mph genes, including mph(K), were first characterized in E. coli, a recent study revealed that S. aureus and Stenotrophomonas maltophilia have mph(C). The mph(C) has a low G+C content, like...Continue Reading

Citations

Jun 14, 2005·Advanced Drug Delivery Reviews·Gerard D Wright
Jan 1, 2008·Interdisciplinary Perspectives on Infectious Diseases·Lixin ZhangBetsy Foxman
Jun 7, 2005·Aquatic Toxicology·Yong-Hak Kim, Carl E Cerniglia
Mar 27, 2007·Cell·Michael N Alekshun, Stuart B Levy
Jan 7, 2015·Saudi Journal of Biological Sciences·Sibhghatulla ShaikhMohammad Amjad Kamal
Feb 17, 2007·FEMS Microbiology Letters·Olivier ChesneauPatrice Courvalin
Apr 21, 2011·Expert Review of Anti-infective Therapy·Iain J AbbottLeon J Worth
Apr 17, 2019·Current Topics in Medicinal Chemistry·Brinda Chandar, Debdutta Bhattacharya
Aug 17, 2019·New Biotechnology·Ana C ReisPhilippe F X Corvini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
B Weisblum
Antimicrobial Agents and Chemotherapy
Sean R ConnellDiane E Taylor
The New England Journal of Medicine
Daniel M MusherKurt L Krause
© 2021 Meta ULC. All rights reserved