Inactivation of medial prefrontal cortex impairs time interval discrimination in rats.

Frontiers in Behavioral Neuroscience
Jieun KimMin Whan Jung

Abstract

Several lines of evidence suggest the involvement of prefrontal cortex in time interval estimation. The underlying neural processes are poorly understood, however, in part because of the paucity of physiological studies. The goal of this study was to establish an interval timing task for physiological recordings in rats, and test the requirement of intact medial prefrontal cortex (mPFC) for performing the task. We established a temporal bisection procedure using six different time intervals ranging from 3018 to 4784 ms that needed to be discriminated as either long or short. Bilateral infusions of muscimol (GABA(A) receptor agonist) into the mPFC significantly impaired animal's performance in this task, even when the animals were required to discriminate between only the longest and shortest time intervals. These results show the requirement of intact mPFC in rats for time interval discrimination in the range of a few seconds.

Citations

Dec 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Min XuMu-ming Poo
May 14, 2016·Current Opinion in Behavioral Sciences·Nandakumar S Narayanan
Dec 17, 2014·Biochemical and Biophysical Research Communications·Yuwei LiuHuilin Yi
Feb 1, 2015·Journal of Physiology, Paris·Mark LaubachNandakumar S Narayanan
May 6, 2014·Frontiers in Behavioral Neuroscience·Nathaniel J Powell, A David Redish
Oct 30, 2016·Journal of Cognitive Neuroscience·Kuan-Hua ChenNandakumar S Narayanan
Nov 18, 2017·Cerebral Cortex·Zoran TiganjMarc W Howard
Dec 18, 2018·PloS One·J Alegre-CortésE Fernandez
Mar 21, 2019·Journal of Neurophysiology·Brandy SchmidtA David Redish
Aug 29, 2018·Frontiers in Integrative Neuroscience·Jieun KimMin Whan Jung
Jul 10, 2021·Neuron·André F de SousaAlcino J Silva

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