Inactivation of mgrB gene regulator and resistance to colistin is becoming endemic in carbapenem-resistant Klebsiella pneumoniae in Greece: A nationwide study from 2014 to 2017.

International Journal of Antimicrobial Agents
Mouna HamelJean-Marc Rolain

Abstract

In Greece, the spread of carbapenem-resistant Enterobacteriaceae in humans has led to the reintroduction of colistin as a therapeutic agent. Unfortunately, colistin resistance with different mechanisms has emerged. The present work aims to determine the prevalence of carbapenem and colistin resistance and the corresponding mechanisms in Klebsiella pneumoniae clinical isolates from Greece. From 2014 to 2017, 288 carbapenem-resistant K. pneumoniae clinical strains were gathered from a collection of 973 isolates from eight different hospitals in Greece. Antibiotic susceptibility testing was performed using three different methods. Screening of carbapenem and colistin resistance genes was conducted using polymerase chain reaction (PCR) amplification and sequencing. Among the 288 (29.6 %) carbapenem-resistant isolates, 213 (73.9%) were colistin-resistant (minimum inhibitory concentration [MIC] >2 mg/L). The KPC type was the most common carbapenemase gene (116; 40.3%), followed by VIM (41; 14.2%), NDM (33; 11.5%) and OXA-48 (22; 7.6%). Moreover, 44 (15.3%) strains co-produced two types of carbapenemases. No mcr genes were detected for colistin resistance but mutations in chromosomal genes were found. These included inactivation of th...Continue Reading

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Citations

Mar 7, 2021·Microorganisms·Mouna HamelSophie Alexandra Baron
Jun 16, 2021·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Paola Amaral de CamposRosineide Marques Ribas
Jul 3, 2021·Diseases·Ozioma Forstinus NwaborSarunyou Chusri
Apr 6, 2021·Deutsches Ärzteblatt International·Robin KöckBirgit Walther
Nov 13, 2021·Frontiers in Cellular and Infection Microbiology·Yanling LiuLingbing Zeng

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