Inactivation of microorganisms and endotoxins by low temperature nitrogen gas plasma exposure

Biocontrol Science
Hideharu ShintaniNobuo Kido

Abstract

The plasma of several different gases has shown a sporicidal activity. From these gases, nitrogen gas was most difficult to produce atomic nitrogen radicals. However, these radicals have a high energy, indicating that nitrogen gas plasma could be used to sterilize microorganisms and inactivate endotoxins. The sterilization mechanism of nitrogen gas plasma is the synergistic effect of a high rising-up voltage pulse, UV irradiation and atomic nitrogen radicals. Thus, the target cells were damaged by degradation, which resulted in death. The biological indicator (BI) used in this study was Geobacillus stearothermophilus ATCC 7953 at a population of 1 x 10(6) CFU/sheet. Sterility assurance was confirmed by using the BI. Moreover, endotoxins were successfully inactivated. More than 5 log reduction of endotoxins could be attained with 30 minutes of nitrogen gas plasma exposure. Material functionality influenced by nitrogen gas plasma presented a satisfactory result. No deterioration of polymers could be observed by nitrogen gas plasma exposure.

Citations

Apr 7, 2009·Biocontrol Science·Hideharu Shintani
Mar 18, 2015·Biointerphases·Alex ShawFelipe Iza
Apr 9, 2017·AMB Express·Akikazu Sakudo, Yuichiro Imanishi
Dec 25, 2015·Biocontrol Science·Kaoru TamazawaHidetoshi Shimauchi
Sep 1, 2010·Experimental and Therapeutic Medicine·Hideharu ShintaniGerald McDonnell
Dec 3, 2016·Molecular Medicine Reports·Akikazu SakudoYuichiro Imanishi
Oct 24, 2019·International Journal of Molecular Sciences·Akikazu SakudoTakashi Onodera
Sep 4, 2020·International Journal of Molecular Sciences·Akikazu Sakudo, Tatsuya Misawa
Mar 31, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yusuke NomuraYuji Haishima

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