Inactivation of Myc-induced p53-dependent apoptosis in human tumors

Apoptosis : an International Journal on Programmed Cell Death
M HenrikssonKlas G Wiman

Abstract

The Myc family of oncoproteins promote cell growth and are frequently overexpressed in human tumors. However, Myc can also trigger cell death by apoptosis. This is at least in part mediated via the ARF-p53 pathway. Myc activation leads to a selection for inactivation of ARF or p53, allowing cell survival and tumor progression. Restoration of p53-dependent apoptosis by various means is an attractive approach for new cancer therapy.

Citations

Feb 13, 2010·Neuro-oncology·Hae-Ri SongAnat Erdreich-Epstein
Jan 1, 2013·ISRN Hepatology·Kewei Wang, Bingliang Lin
Mar 31, 2006·Journal of Cellular Biochemistry·Ami AlbihnMarie Henriksson
Mar 21, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sung-Suk SuhCarlo M Croce
Aug 7, 2003·Oncogene·Mikael S Lindström, Klas G Wiman
Mar 25, 2014·Biochimica Et Biophysica Acta·Steven Fletcher, Edward V Prochownik
Jul 1, 2002·Environmental Toxicology and Pharmacology·S AlexandreP Vasseur

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