Inactivation of protein tyrosine phosphatases by dietary isothiocyanates

Bioorganic & Medicinal Chemistry Letters
Sarah M LewisKent S Gates

Abstract

Isothiocyanates are bioactive dietary phytochemicals that react readily with protein thiol groups. We find that isothiocyanates are time-dependent inactivators of cysteine-dependent protein tyrosine phosphatases (PTPs). Rate constants for the inactivation of PTP1B and SHP-2 by allyl isothiocyanate and sulforaphane range from 2 to 16 M(-1)s(-1). Results in the context of PTP1B are consistent with a mechanism involving covalent, yet reversible, modification of the enzyme's active site cysteine residue.

References

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Citations

May 24, 2017·Molecular BioSystems·Kasi Viswanatharaju Ruddraraju, Zhong-Yin Zhang
Mar 29, 2019·Bioscience, Biotechnology, and Biochemistry·Maiko ChibaTakashi Nagasawa
Jan 27, 2018·Journal of Clinical Biochemistry and Nutrition·Toshiyuki NakamuraYoshimasa Nakamura
Jul 8, 2020·Nutrients·Antonio Pérez-PérezVíctor Sánchez-Margalet

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