Inactivation of rabbit immunoglobulin lambda chain variable region genes by the insertion of short interspersed elements of the C family

European Journal of Immunology
D J Hayzer, J C Jaton

Abstract

Two rabbit germ-line genes encoding immunoglobulin lambda light chain V regions were cloned from a rabbit genomic liver DNA library and characterized. One, V lambda 1, is separated by at least 8 kb from any other V lambda gene. The second, V lamdba 4, forms part of a three-gene cluster with two functional V lambda genes recently reported. Both V lambda 1 and V lambda 4 have structural features rendering them pseudogenes. The coding regions have frame-shift mutations which would yield defective protein products; both genes are also interrupted by the insertions of short, interspersed repetitive elements of the C family. In the V lambda 1 gene, the 369-bp insert is located upstream of the gene between the putative TATA box and the leader exon, whereas in gene V lambda 4, the 360-bp insert interrupts the FR2 at codon 48c. In addition, the sequence of the complement-determining region 3 of gene V lambda 1 is very similar to the mouse DSP2.6 sequence.

References

May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·E A KabatH Bilofsky
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·S TonegawaW Gilbert
May 1, 1987·European Journal of Immunology·R DildropK Rajewsky
Jan 1, 1986·Annual Review of Immunology·G D Yancopoulos, F W Alt
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P SanchezP A Cazenave
Feb 25, 1985·Nucleic Acids Research·R C Hardison, R Printz
Jan 1, 1982·The Journal of Experimental Medicine·Y Kurosawa, S Tonegawa

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Citations

Jan 1, 1995·Molecular Immunology·L Y Ch'angA Solomon
Dec 1, 1990·European Journal of Immunology·D J HayzerJ C Jaton
Jan 1, 1997·International Reviews of Immunology·K L Knight, C R Winstead

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